63819-86-3

Basic information

• Product Name: Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate
• CAS NO: 63819-86-3
• Molecular Weight: 229.233
• Mol File: 63819-86-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate(63819-86-3)
• EPA Substance Registry System: Methyl 3-nitro-2-(3-oxocyclohexyl)propanoate(63819-86-3)

Safety Data

• Hazardous Substances Data: 63819-86-3(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 20497-95-4 methyl 3-nitropropionate 

Relevant articles and documents

Doubly Deprotonated Methyl 3-Nitropropanoate, an Acrylic Ester d2-Reagent

Methyl 3-nitropropanoate can be doubly deprotonated with LDA, both in the α-nitro and in the α-carbonyl position (-> 1).It is shown that the necessary cosolvent HMPT can be replaced by the cyclic urea DMPU, with almost equal results.The new reagent 1 is alkylated and hydroxyalkylated by alkyl halides and aldehydes, respectively, at the 2-position exclusively (see 2, 4, 6, 7).A double alkylation to methyl α,α-dialkyl-β-nitropropanoate 5 is possible.Elimination of HNO2 with DBN or even better with DBU in THF furnishes methyl α-methylenealkanoates 9 and methyl β-hydroxy-α-methylenealkanoates 10.