205371-31-9Relevant articles and documents
New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies
Sundriyal, Sandeep,Viswanad, Bhoomi,Ramarao, Poduri,Chakraborti, Asit K.,Bharatam, Prasad V.
scheme or table, p. 4959 - 4962 (2009/05/30)
A new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand bin
Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists
Cai, Zhefeng,Feng, Jun,Guo, Yanshen,Li, Pingping,Shen, Zhufang,Chu, Fengming,Guo, Zongru
, p. 866 - 874 (2007/10/03)
A series of azaindole-α-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure-activity relationship was developed for PPARα/γ dual agonism. One of the synthesized compound 7a was identified as a potent