52191-15-8Relevant articles and documents
Adsorption, micellization and antimicrobial activity of formyl-containing cationic surfactant in diluted aqueous solutions
He, Shuai,Lu, Pingping,Zhang, Yongmin,Zhou, Yue
, (2021)
Surfactants based on dynamic covalent bonds have attracted significant interest over the past few decades due to the coexistence of covalent and non-covalent bonds. However, studies on the fundamental properties of their precursors are rare. Herein, we synthesized a series of formyl-containing cationic surfactants (N-alkyl-N,N-dimethyl-N-(2-(4-formyl-phenoxy)ethyl) ammonium bromides) bearing different hydrophobic chains, which can form dynamic imine bonds. The adsorption, micellization and antimicrobial activity were systematically investigated using surface tension, fluorescence, electrical conductivity, and ITC techniques. The results showed that the insertion of the 2-(4-formyl-phenoxy)ethyl group (equivalent to ~7 methylene groups) endows the surfactant with an asymmetrical double-chain structure, enhancing the hydrophobic interaction. As a result, the critical micelle concentration (cmc) and contribution per methylene group to the standard Gibbs free energy of micellization (?Gmo) were significantly decreased, compared to conventional single surfactant. Upon increasing the hydrophobic chain length, the cmc, the negative logarithm of the surfactant concentration in the bulk phase required to produce a 20 mN·m?1 reduction in the surface tension of the solvent (pC20) and maximum surface excess amount of the adsorbed surfactant (Γmax) all decreased accompanied by an increase in the minimum molecular occupation area (Amin), while the ?Gmo and standard Gibbs free energy of adsorption (?Gadso) become more negative and thus more favorable for the formation of micelles and the adsorption film. Moreover, micellization changed from being entropy-driven to enthalpy-driven and is more sensitive toward NaCl than urea. In addition, the current formyl-containing cationic surfactants exhibit excellent antimicrobial activity against both Gram-positive and Gram-negative bacteria and fungi, especially the surfactant with a hydrophobic chain containing ~20 atoms. Such a study will be favorable for the design of new dynamic covalent surfactants and an understanding of the change in their aggregation.
'Naked-eye' quinoline-based 'reactive' sensor for recognition of Hg2+ ion in aqueous solution
Zhang, Yanhua,Yan, Yuanyuan,Chen, Suying,Gao, Zhinan,Xu, Hui
, p. 5373 - 5376 (2014)
A new 'naked-eye' quinoline-based 'reactive' ratiometric fluorescent probe was prepared. The reactive stoichiometry of the probe with Hg2+ ion was 2:1. The probe exhibited high selectivity towards Hg2+ ion to other metal ions with a
Construction of pH-Responsive Supramolecular Assemblies Based on Dynamic Covalent Bonds for Tunable Drug Release
Sun, Panpan,Lu, Fei,Wu, Aoli,Yin, Yue,Shi, Lijuan,Zheng, Liqiang
, p. 593 - 600 (2018)
In the present work, we propose a novel strategy for preparing supramolecular self-assemblies for pH-responsive drug delivery. In alkaline solutions, a novel supra-amphiphile can be fabricated by a cationic surfactant dodecyl[2-(4-formylphenoxy)ethyl] dim
Study of the structure-bioactivity of fleximers: synthesis, crystal structure, Hirshfeld surface analysis, and anti-inflammatory assays
Singh, Ved Prakash,Dowarah, Jayanta,Marak, Brilliant N.,Sran, Balkaran Singh,Tewari, Ashish Kumar
, (2021)
Synthesized and natural pyridones/pyridines derivatives exhibiting diverse biological activities. 2-pyridone has lactam-lactim tautomerization like thymine and uracil bases. In this study, COX-2 target based series of pyridone/pyridine linked fleximers were designed, synthesized and studied. All analogues binding affinity with COX-2 active site were studied through molecular docking, and anti-inflammatory activity studied by in vivo analysis. Weak interactions were studied to find binding sites among analogues through crystal packing, Hirshfeld surface analysis and in silico analysis. All the analogues exhibited anti-inflammatory activity, while compound (3) is the most active analogue among the series. In contrast, since compound (3) is a pyridine-phthalimide ring-containing analogue, the presence of a phthalimide group probably favors anti-inflammatory activity over other types of rings. The results suggested further investigations on compounds as anti-inflammatory prodrugs.
Photophysical properties and photodynamic anti-tumor activity of corrole-coumarin dyads
Cheng, Fan,Wang, Hua-Hua,Ali, Atif,Kandhadi, Jaipal,Wang, Hui,Wang, Xiang-Li,Liu, Hai-Yang
, p. 886 - 898 (2018)
A new non-conjugated corrole-coumarin dyad and its gallium complex has been synthesized. Photophysical properties of the dyads were tested in two solvents, exhibiting strong solvent effect on the absorption and fluorescence spectra. Absorption spectra of
Efficient combination of calix[4]arenes and meso-diphenylporphyrins
Milbradt,Weiss
, p. 2999 - 3002 (1995)
The selective mono-alkylation of a calix[4]arene with a functionalized benzaldehyde followed by the condensation with dipyrrylmethane afforded in good yield a porphyrin substituted by two calix[4]arenes. The same multisite ligand was alternatively obtaine
New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies
Sava, Alexandru,Buron, Frederic,Routier, Sylvain,Panainte, Alina,Bibire, Nela,Profire, Lenu?a
, (2021/05/10)
In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a–s), as a new safer and efficient multi-targets strategy for inflammatory diseases. The che
One-Photon Excitation Followed by a Three-Step Sequential Energy–Energy–Electron Transfer Leading to a Charge-Separated State in a Supramolecular Tetrad Featuring Benzothiazole–Boron-Dipyrromethene–Zinc Porphyrin–C60
Badgurjar, Deepak,Seetharaman, Sairaman,D'Souza, Francis,Chitta, Raghu
supporting information, p. 2184 - 2195 (2020/12/25)
A panchromatic triad, consisting of benzothiazole (BTZ) and BF2-chelated boron-dipyrromethene (BODIPY) moieties covalently linked to a zinc porphyrin (ZnP) core, has been synthesized and systematically characterized by using 1H NMR s
