206192-43-0Relevant articles and documents
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases
Levin, Jeremy I.,Gu, Yansong,Nelson, Frances C.,Zask, Arie,DiJoseph, John F.,Sharr, Michele A.,Sung, Amy,Jin, Guixian,Cowling, Rebecca,Chanda, Pranab,Cosmi, Scott,Hsiao, Chu-Lai,Edris, Wade,Wilhelm, James,Killar, Loran M.,Skotnicki, Jerauld S.
, p. 239 - 242 (2001)
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.
THE PREPARATION AND USE OF ORTHO-SULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS
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, (2008/06/13)
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF- alpha converting enzyme (TACE, tumor necrosis factor- alpha conve
PREPARATION AND USE OF ORTHOSULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITIORS
-
, (2008/06/13)
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e. g. gelatinases, stromelysins and collagenases) and TNF-α converting enzyme (TACE, tumor necrosis factor-α converting enz