206192-58-7

Basic information

• Product Name: 5-bromo-4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester
• Synonyms: 5-bromo-4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester
• CAS NO: 206192-58-7
• Molecular Weight: 406.278
• Mol File: 206192-58-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-bromo-4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester(206192-58-7)
• EPA Substance Registry System: 5-bromo-4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester(206192-58-7)

Safety Data

• Hazardous Substances Data: 206192-58-7(Hazardous Substances Data)

Upstream product

• 206192-43-0 4-(4-methoxy-benzenesulfonylamino)-thiophene-3-carboxylic acid methyl ester 
• 69363-85-5 methyl 4-aminothiophene-3-carboxylate 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Downstream Products

• 206192-59-8 4-[benzyl-(4-methoxy-benzenesulfonyl)-amino]-5-bromo-thiophene-3-carboxylic acid methyl ester 
• 206192-63-4 4-[Benzyl-(4-methoxy-benzenesulfonyl)-amino)-5-ethynyl-thiophene-3-carboxylic acid 
• 206192-62-3 4-[benzyl-(4-methoxy-benzenesulfonyl)-amino]-5-ethynyl-thiophene-3-carboxylic acid methyl ester 
• 206192-60-1 4-[benzyl-(4-methoxy-benzenesulfonyl)-amino]-5-bromo-thiophene-3-carboxylic acid 
• 206192-66-7 5-Bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-thiophene-3-carboxylic acid 
• 206192-65-6 5-bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-thiophene-3-carboxylic acid methyl ester 

Relevant articles and documents

HETEROARYL ACETYLENIC SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS

Compounds of formula (I) are useful in treating disease conditions mediated by TNF- alpha such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.

PREPARATION AND USE OF ORTHOSULFONAMIDO HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITIORS

The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e. g. gelatinases, stromelysins and collagenases) and TNF-α converting enzyme (TACE, tumor necrosis factor-α converting enz