20638-90-8

Basic information

• Product Name: retinonitrile
• CAS NO: 20638-90-8
• Molecular Weight: 281.441
• Mol File: 20638-90-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: retinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: retinonitrile(20638-90-8)
• EPA Substance Registry System: retinonitrile(20638-90-8)

Safety Data

• Hazardous Substances Data: 20638-90-8(Hazardous Substances Data)

Upstream product

• 6980-79-6 (2E,4E,6E)-5-Methyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-2,4,6-trienal 
• 58526-71-9 (2E,4E,6E)-5-methyl-7-(2’,6’,6’-trimethylcyclohex-1’-en-1’-yl)-hepta-2,4,6-trienenal 
• 62924-18-9 β-ionylidene-acetonitrile 
• 72214-33-6 3-(2,6,6-Trimethylcyclohex-1-enyl)prop-2-enenitrile 
• 472-80-0 beta-Ionol 
• 53018-97-6 3-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-propenal 
• 3917-41-7 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal 
• 79-77-6 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one 
• 5560-99-6 (2X,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienal 
• 82648-70-2 diethyl (3-cyano-2-methyl-2-trans-propenyl)phosphonate 
• 21658-95-7 diisopropyl (cyanomethyl)phosphonate 
• 1220-77-5 6-methyl-8-(2,6,6-trimethyl-1-cyclohexenyl)-3,5,7-octatriene-2-one 
• 141207-99-0 N-methoxy-N,5-dimethyl-7-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6-heptanetrienamide 
• 110875-15-5 (4E,6E,8E)-3,7-dimethyl-3-hydroxy-9-(2,6,6-trimethyl-1-cyclohexenyl)-4,6,8-nonatrienenitrile 

Downstream Products

• 116-31-4 all-trans-Retinal 
• 87391-97-7 <15-13C>13-cis-retinal 
• 78508-47-1 C₁₉⁽¹³⁾CH₂₈O 
• 99302-30-4 retinal 
• 99302-31-5 retinal 
• 472-86-6 13-cis-vitamin A aldehyde 
• 7235-40-7 beta-carotene 
• 1436-55-1 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal 

Relevant articles and documents

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.

Preparation of (9Z, 11Z) - Vitamin A

Starting from (7E,9Z)-C15-aldehyde 4, the syntheses of (9Z, 11Z)-vitamin A acetate and palmitate are reported. The construction strategy is based on treatment of 4 with Zn-PPh3/CBr4, addition of acetaldehyde followed by a

SYNTHETIC INVESTIGATIONS IN THE CHEMISTRY OF POLYENE COMPOUNDS. L. SYNTHESIS OF THE NITRILES AND HYDROXYNITRILES OF RETINOIC ACID

Glycidonitrile was synthesized from 9-methyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-9,11-octadien-13-one and chloroacetonitrile by a modified Darzens reaction.Opening of the epoxide ring in the glycidonitrile gave 9,14-dihydroxy-9,13-dimethyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-10,12-nonadiene-15-nitrile with a yield of 70percent calculated on the ketone.Partial dehydration of the latter gave 14-hydroxy-9,13-dimethyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-8,10,12-nonatriene-15-nitrile - the key compound in the synthesis of the biologically active analog of the vitamin Ametabolite.The total dehydration of the dihydroxynitrile led to retinonitrile.