206532-57-2Relevant articles and documents
Synthesis of (+)- and (-)-ethosuximides utilizing asymmetric nitroolefination
Nishide, Kiyoharu,Katoh, Takahiro,Imazato, Hitoshi,Node, Manabu
, p. 839 - 845 (2007/10/03)
Both enantiomers of ethosuximide were synthesized from (S)-(-)- and (R)-(+)-2-methyl-2-[(E)-2-nitroethenyl]-γ-butyrolactones (1), which were obtained by asymmetric nitroolefination of α-methyl-γ-butyrolactone, via the lactone carboxylic acid (3).