20677-12-7

Basic information

• Product Name: DIETHYL(4-BROMOPHENYL)PHOSPHONATE
• Synonyms: DIETHYL(4-BROMOPHENYL)PHOSPHONATE;Diethyl(4-bromophenyl)phosphonate, 98 %;Diethyl (p-bromophenyl)phosphonate;Diethyl 4-bromobenzenephosphonate;Diethyl p-bromobenzenephosphonate;P-(4-Bromophenyl)phosphonic acid diethyl ester;Phosphonic acid,P-(4-bromophenyl)-, diethyl ester;1-Bromo-4-diethoxyphosphorylbenzene
• CAS NO: 20677-12-7
• Molecular Formula: C₁₀H₁₄BrO₃P
• Molecular Weight: 293.09
• Mol File: 20677-12-7.mol
• Article Data: 37

Chemical Properties

• Melting Point: 73-75℃
• Boiling Point: 120°C/0.4mmHg(lit.)
• Appearance: /
• Density: 1.41
• Refractive Index: 1.5240 to 1.5280
• CAS DataBase Reference: DIETHYL(4-BROMOPHENYL)PHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL(4-BROMOPHENYL)PHOSPHONATE(20677-12-7)
• EPA Substance Registry System: DIETHYL(4-BROMOPHENYL)PHOSPHONATE(20677-12-7)

Safety Data

• Hazardous Substances Data: 20677-12-7(Hazardous Substances Data)

Usage

General Description

DIETHYL(4-BROMOPHENYL)PHOSPHONATE is a chemical compound that contains two ethyl groups and a 4-bromophenyl group attached to a phosphorus atom. It is commonly used as a flame retardant and in the synthesis of pharmaceuticals and agrochemicals. It is a highly toxic and flammable liquid that should be handled with care. The compound has low solubility in water but is soluble in organic solvents. It is important for researchers, manufacturers, and users to follow proper safety protocols when working with this chemical due to its hazardous nature.

Upstream product

• 108-86-1 bromobenzene 
• 106-37-6 1.4-dibromobenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 589-87-7 1,4-bromoiodobenzene 
• 814-49-3 diethyl chlorophosphate 
• 762-04-9 Diethyl phosphonate 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 5467-74-3 4-Bromophenylboronic acid 
• 673-40-5 4-bromobenzenediazonium tetrafluoroborate 
• 122-52-1 triethyl phosphite 
• 139139-81-4 bis(4-bromophenyl)iodonium triflate 
• 34176-08-4 sodium 4-bromobenzenesulfinate 
• 16839-13-7 4-bromophenylphosphonic acid 
• 589-21-9 (4-bromophenyl)hydrazine 

Downstream Products

• 16839-13-7 4-bromophenylphosphonic acid 
• 42822-57-1 diethyl (4-aminophenyl)phosphonate 
• 561023-72-1 (4-[2,2']bithiophenyl-5-yl-phenyl)-phosphonic acid diethyl ester 
• 179941-24-3 diethyl [4-[5-(2,4-diamino-pyrimidin-5-yl-methyl)-2,3-dimethoxy-phenylethynyl]-phenyl]-phosphonate 
• 914656-95-4 bromo [4-(diethoxyphosphoryl)phenyl]zinc 
• 1362019-95-1 4-bromo-4'-(diisopropylsilyl)-E-stilbene 
• 1564250-34-5 1,1'-(1,2,3,4-diethynyl)diphenyl-4,4'-bisphosphonate 
• 366017-60-9 diethyl [4-((trimethylsilyl)ethynyl)phenyl]phosphonate 
• 4648-58-2 (4-Bromophenyl)phosphonsaeure-dichlorid 
• 1616557-91-5 C₁₀H₁₀BrOP 
• 1616558-16-7 C₁₇H₁₉BrNOP 
• 1616557-92-6 C₁₅H₂₁BrNO₃P 

Relevant articles and documents

Palladium-catalyzed one-pot phosphorylation of phenols mediated by sulfuryl fluoride

We report a general palladium-catalyzed one-pot procedure for the synthesis of phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride. It features mild conditions, broad substrate scope, high functionality tolerance and water insensitivity. The utility of this procedure has been well demonstrated by gram-scale synthesis, sequential synthesis of click chemistry building blocks, late-stage decoration of drugs and natural products and on-DNA synthesis of phosphine oxide for a DNA-encoded library (DEL).

Investigation of Immobilization Effects on Ni(P2N2)2Electrocatalysts

A new synthetic route to complexes of the type Ni(P2N2)22+ with highly functionalized phosphine substituents and the investigation of immobilization effects on these catalysts is reported. Ni(P2N2)22+ complexes have been extensively studied as homogeneous and surface-attached molecular electrocatalysts for the hydrogen evolution reaction (HER). A synthesis based on postsynthetic modification of PArBr2NPh2 was developed and is described here. Phosphonate-modified ligands and their corresponding nickel complexes were isolated and characterized. Subsequent deprotection of the phosphonic ester derivatives provided the first Ni(P2N2)22+ catalyst that can be covalently attached via pendent phosphonate groups to an electrode without involvement of the important pendent amine groups. Mesoporous TiO2 electrodes were surface modified by attachment of the new phosphonate functionalized Ni(P2N2)22+ complexes, and these provided electrocatalytic materials that proved to be competent and stable for sustained HER in aqueous solution at mild pH and low overpotential. We directly compared the new ligand to a previously reported complex that utilized the amine moiety for surface attachment. Using HER as the benchmark reaction, the P-attached catalyst showed a marginally (9-14%) higher turnover number than its N-attached counterpart.

NAPHTHYRIDINE DERIVATIVES AS PRC2 INHIBITORS

Disclosed are compounds of formula (I) or (II) that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.