42822-57-1

Basic information

• Product Name: DIETHYL(4-AMINOPHENYL)PHOSPHONATE
• Synonyms: CHEMPACIFIC 60129;DIETHYL(4-AMINOPHENYL)PHOSPHONATE;(4-AMINO-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER;Diethyl(4-aminophenyl)phosphonate, min. 95 %;4-(Diethoxyphosphoryl)aniline, 4-(Diethylphosphono)aniline;Diethyl (4-aminophenyl)phosphonate 95%;Diethyl(4-aminophenyl)phosphonate95%;Diethyl (4-aminophenyl)
• CAS NO: 42822-57-1
• Molecular Formula: C₁₀H₁₆NO₃P
• Molecular Weight: 229.21
• Mol File: 42822-57-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 341.6°C at 760 mmHg
• Flash Point: 160.4°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 7.94E-05mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.51±0.10(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: DIETHYL(4-AMINOPHENYL)PHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL(4-AMINOPHENYL)PHOSPHONATE(42822-57-1)
• EPA Substance Registry System: DIETHYL(4-AMINOPHENYL)PHOSPHONATE(42822-57-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 42822-57-1(Hazardous Substances Data)

Usage

General Description

DIETHYL(4-AMINOPHENYL)PHOSPHONATE is a chemical compound that is commonly used as an intermediate in the synthesis of various organic phosphorous compounds. It is a phosphonate ester, which means it contains a phosphorus atom bonded to two oxygen atoms and an organic group. This particular compound contains an ethyl group and a 4-aminophenyl group linked to the phosphorus atom. It is often employed in organic chemistry reactions to introduce the phosphonate group into organic molecules, and can also be used as a flame retardant additive in polymers and plastics. Additionally, it has been studied for its potential uses in pharmaceuticals and agrochemicals due to its unique chemical properties.

InChI:InChI=1/C10H16NO3P/c1-3-13-15(12,14-4-2)10-7-5-9(11)6-8-10/h5-8H,3-4,11H2,1-2H3

Upstream product

• 20677-12-7 diethyl (4-bromophenyl)phosphonate 
• 762-04-9 phosphonic acid diethyl ester 
• 540-37-4 p-aminoiodobenzene 
• 29800-93-9 diethyl phosphite 
• 1754-42-3 para-nitro-phenylphosphonate diethylique 
• 367-24-8 4-bromo-2-fluoroaniline 
• 106-40-1 4-bromo-aniline 
• 615-57-6 2,4-dibromo-aniline 
• 89620-99-5 silver diethyl phosphonate 
• 62956-32-5 4-acetylaminophenylphosphonic acid diethyl ester 
• 1246999-26-7 diethyl 4-(4-hydroxy-phenylazo)phenylphosphonate 
• 586-78-7 para-nitrophenyl bromide 
• 122-52-1 triethyl phosphite 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 28255-39-2 diethyl (4-hydroxyphenyl)phosphonate 
• 5337-17-7 4-aminophenylphosphonic acid 
• 103697-17-2 (4-iodophenyl)phosphonate de diethyle 
• 345352-13-8 (4-isocyanato-phenyl)-phosphonic acid diethyl ester 
• 242804-94-0 C₂₈H₄₂N₄O₈P₂ 

Relevant articles and documents

STRAD-BINDING AGENTS AND USES THEREOF

Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.

Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors

Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase so far. The aim of this research was to develop novel and selective phosphorus containing CDK9/CycT1 inhibitors. Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized. Prepared compounds were evaluated in an enzymatic CDK9/CycT1 assay. The most potent molecules were tested in cell-based toxicity and HIV proliferation assays. Selectivity of shortlisted compounds against CDKs and other kinases was tested. The best compound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.

An improved procedure for the synthesis of aryl phosphonates by palladium-catalysed cross-coupling of aryl halides and diethyl phosphite in polyethylene glycol

A general and greener protocol for the synthesis of aryl phosphonates by the cross-coupling of aryl halides and diethyl phosphite using tetrakis(triphenylphosphine)palladiume/triethylamine/polyethylene glycol 600 [Pd(PPh3)4/ Et3N/PEG 600] as an efficient catalytic system has been developed. This procedure also avoids hazardous solvents and is therefore an eco-friendly alternative to the existing methods.