207233-99-6

Basic information

• Product Name: 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99
• Synonyms: 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99;2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99%
• CAS NO: 207233-99-6
• Molecular Formula: C14H12F3NO
• Molecular Weight: 267.2463896
• Mol File: 207233-99-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-105 °C(lit.)
• Boiling Point: 350°Cat760mmHg
• Flash Point: 165.5°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 4.53E-05mmHg at 25°C
• Refractive Index: 1.513
• PKA: -5.93±0.70(Predicted)
• CAS DataBase Reference: 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99(207233-99-6)
• EPA Substance Registry System: 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99(207233-99-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 207233-99-6(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99, also known as Flumazenil, is a chemical compound with a molecular formula of C13H10F3NO. It is a white to light beige crystalline powder with a purity of 99%. Flumazenil is a benzodiazepine antagonist, meaning it can reverse the effects of benzodiazepine drugs by competing for the same receptor sites in the central nervous system, effectively blocking their effects. It is commonly used in clinical settings to reverse the sedative and anxiolytic effects of benzodiazepines, particularly in cases of overdose or during anesthesia recovery. 2,5-DIMETHYL-1-(3-(TRIFLUOROMETHYL)-PHENYL)PYRROLE-3-CARBOXALDEHYDE, 99 has applications in the pharmaceutical industry and research laboratories for the development of medications and the study of neurotransmitter receptors.

InChI:InChI=1/C14H12F3NO/c1-9-6-11(8-19)10(2)18(9)13-5-3-4-12(7-13)14(15,16)17/h3-8H,1-2H3

Upstream product

• 110-13-4 2,5-hexanedione 
• 98-16-8 3-trifluoromethylaniline 
• 570-04-7 2,5-dimethyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1428183-47-4 C₂₂H₂₁F₃N₂O₃ 

Relevant articles and documents

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 μM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.

Discovery and optimisation studies of antimalarial phenotypic hits

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the physicochemical properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09e29 mM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds.