570-04-7

Basic information

• Product Name: 2,5-DIMETHYL-1-(3-TRIFLUOROMETHYL-PHENYL)-1H-PYRROLE
• Synonyms: 2,5-DiMethyl-1-[3-(trifluoroMethyl)phenyl]pyrrole
• CAS NO: 570-04-7
• Molecular Formula: C₁₃H₁₂F₃N
• Molecular Weight: 239.24
• Mol File: 570-04-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 288.9°Cat760mmHg
• Flash Point: 128.5°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.00394mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 2,5-DIMETHYL-1-(3-TRIFLUOROMETHYL-PHENYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-1-(3-TRIFLUOROMETHYL-PHENYL)-1H-PYRROLE(570-04-7)
• EPA Substance Registry System: 2,5-DIMETHYL-1-(3-TRIFLUOROMETHYL-PHENYL)-1H-PYRROLE(570-04-7)

Safety Data

• Hazardous Substances Data: 570-04-7(Hazardous Substances Data)

Usage

Biological Activities

Antimicrobial: Potential to inhibit the growth of microorganisms.
Antifungal: Ability to combat fungal infections.
Antioxidant: Capable of neutralizing harmful free radicals in biological systems.

Medicinal Chemistry & Pharmaceutical Research

Interest in exploring its pharmacological properties for potential therapeutic applications.

Synthetic Utility

Used as a building block in the synthesis of more complex organic molecules.

Industrial Applications

Potential use in various industrial processes.

Material and Technological Development

Potential involvement in the development of new materials and technologies.

InChI:InChI=1/C13H12F3N/c1-9-6-7-10(2)17(9)12-5-3-4-11(8-12)13(14,15)16/h3-8H,1-2H3

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 110-13-4 2,5-hexanedione 
• 98-46-4 3-trifluoromethylnitrobenzene 

Downstream Products

• 207233-99-6 2,5-dimethyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carbaldehyde 

Relevant articles and documents

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 μM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

The Paal-Knorr reaction revisited. A catalyst and solvent-free synthesis of underivatized and N-substituted pyrroles

A new, modified synthesis of pyrroles is described. The reaction of 2,5-hexandione with a variety of amines yielded the expected pyrrole analogues in excellent yields. The reactions were carried out under the ultimate green conditions excluding both catalyst and solvent applying simple stirring at room temperature. The variety of amines include aqueous ammonium hydroxide for the synthesis of pyrroles with a free NH group, and benzylamines, anilines and phenylene-diamines for the synthesis of several N-derivatized pyrroles. The reaction also occurs efficiently with a variety of 1,4-diketones, although the reaction rates and yields are lower for the diketones that do not possess terminal methyl group(s). This journal is