20734-71-8

Basic information

• Product Name: 2-methoxy-3-nitrophenol
• Synonyms: 2-methoxy-3-nitrophenol
• CAS NO: 20734-71-8
• Molecular Weight: 169.137
• Mol File: 20734-71-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 70°C
• Boiling Point: 298.4°C (rough estimate)
• Density: 1.3375 (estimate)
• Refractive Index: 1.5830 (rough estimate)
• CAS DataBase Reference: 2-methoxy-3-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-3-nitrophenol(20734-71-8)
• EPA Substance Registry System: 2-methoxy-3-nitrophenol(20734-71-8)

Safety Data

• Hazardous Substances Data: 20734-71-8(Hazardous Substances Data)

Upstream product

• 89625-34-3 1-acetoxy-2-methoxy-3-nitro-benzene 
• 91-23-6 2-Nitroanisole 
• 90-05-1 2-methoxy-phenol 
• 613-70-7 2-methoxyphenyl acetate 
• 2785-95-7 3-lithio-1,2-dimethoxybenzene 
• 6299-67-8 2,3-dimethoxyaniline 
• 91-16-7 1,2-dimethoxybenzene 
• 85630-19-9 N,N-diethyl-1-carbamyloxy-2-methoxybenzene 
• 858647-49-1 2-methoxy-3-nitro-6-(trimethylsilyl)phenyl N,N-diethylcarbamate 
• 858647-47-9 2-methoxy-3-nitrophenyl N,N-diethylcarbamate 
• 116668-84-9 3-nitroveratrole 
• 121001-03-4 3-nitrosoveratrole 

Downstream Products

• 861774-96-1 5.6-diamino-guaiacol 
• 71089-33-3 1,2-dimethoxy-3,4-dinitro-benzene 
• 876478-36-3 5.6-dinitro-guaiacol 

Relevant articles and documents

Iron-catalyzed arene C-H hydroxylation

The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the relative inertness of aryl carbon-hydrogen bonds, the higher reactivity of the phenolic products leading to over-oxidized by-products, and the frequently insufficient regioselectivity. We report that iron coordinated by a bioinspired L-cystine-derived ligand can catalyze undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant. The reaction is distinguished by its broad substrate scope, excellent selectivity, and good yields, and it showcases compatibility with oxidation-sensitive functional groups, such as alcohols, polyphenols, aldehydes, and even a boronic acid. This method is well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug molecules.

Alpha2C adrenoreceptor agonists

In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.

Nucleophilic photosubstitutions of o-methoxynitrobenzenes

We report a new synthesis of 3-nitroveratrole, based on the directed lithiation of veratrole, and photochemical substitutions of both 3-nitroveratrole and o-nitroanisole with several nucleophiles.Both aromatic substrates undergo photocyanation meta to the nitro group.With hydroxide ion, 3-nitroveratrole reacts meta to the nitro group, but 2-nitroanisole undergoes replacement of either substituent, the proportion of reaction at each site depending upon the OH(-) concentration. 3-Nitroveratrole undergoes an inefficient reaction with butylamine at each methoxy group; this reaction is apparently second order in amine.The reaction between o-nitroanisole and diethylamine results only in photohydrolysis.Keywords: photosubstitution, nucleophilic, 3-nitroveratrole, o-nitroanisole