207672-43-3

Basic information

• Product Name: 4β-(2-propenyl)-5,6-secocholestan-3-one
• Synonyms: 4β-(2-propenyl)-5,6-secocholestan-3-one
• CAS NO: 207672-43-3
• Molecular Weight: 428.742
• Mol File: 207672-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4β-(2-propenyl)-5,6-secocholestan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-(2-propenyl)-5,6-secocholestan-3-one(207672-43-3)
• EPA Substance Registry System: 4β-(2-propenyl)-5,6-secocholestan-3-one(207672-43-3)

Safety Data

• Hazardous Substances Data: 207672-43-3(Hazardous Substances Data)

Upstream product

• 207672-36-4 3,3-ethylenedioxy-5-oxo-5,6-secocholestan-6-al 
• 207672-38-6 3,3-ethylenedioxy-5-oxo-5,6-secocholestan-6-ol 
• 207672-39-7 3,3-ethylenedioxy-5,6-secocholest-6-en-5-one 
• 207672-40-0 3,3-ethylenedioxy-5,6-secocholestan-5-one 
• 3496-88-6 3,3-ethylenedioxycholest-5-ene 
• 556-56-9 allyl iodid 
• 207672-41-1 5,6-secocholest-4-en-3-one 

Relevant articles and documents

Synthesis of 4α-(2-propenyl)-5,6-secocholestan 3α-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan- 3α-ol

4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up- regulator and had demonstrated to be an effective agent in lowering plasma cholesterol levels in hypercholesterolemic hamsters. In order to investigate the effect of flexibility of the 3α-hydroxy-bearing A-ring on the activity, 4α-(2-propenyl)-5,6-secocholestan-3α-ol (11), a B-ring seco analog of LY295427, is thus synthesized from cholest-4-en-3-one. Test results indicate that 11 is not active in the CHO cell-based LDL receptor/luciferase assay at concentrations up to 20 μg/mL. The result underlines the importance of maintaining the A-B-C-D ring rigidity of the 3α-sterols in terms of binding to the putative oxysterol receptor.