20776-51-6

Basic information

• Product Name: 2-AMINO-3-BROMOBENZOIC ACID
• Synonyms: 2-AMino-3-broMobenzoic acid, 95+%;3-Bromoanthralic acid, 2-Bromo-6-carboxyaniline;Benzoic acid, 2-amino-3-bromo-;2-AMINO-3-BROMOBENZOIC ACID;AURORA KA-6184;BUTTPARK 49\07-48;2-Amino-3-bromobenzoic acid 97%;3-Bromoanthralic acid
• CAS NO: 20776-51-6
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.03
• EINECS: 1533716-785-6
• Product Categories: Chemical Synthesis;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Carboxylic Acids;Phenyls & Phenyl-Het;Amines;Building Blocks;C7
• Mol File: 20776-51-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 343.5 °C at 760 mmHg
• Flash Point: 161°C
• Appearance: White to pale yellow/Solid
• Density: 1.793 g/cm³
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-BROMOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BROMOBENZOIC ACID(20776-51-6)
• EPA Substance Registry System: 2-AMINO-3-BROMOBENZOIC ACID(20776-51-6)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 22-36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 20776-51-6(Hazardous Substances Data)

Usage

Description

2-Amino-3-bromobenzoic acid is an organic compound that features a benzene ring with an amino group at the 2nd position and a bromine atom at the 3rd position. It is a white to light yellow crystal powder known for its pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
2-Amino-3-bromobenzoic acid is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to serve as a building block in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
2-Amino-3-bromobenzoic acid is also utilized in chemical synthesis for creating a range of compounds with different applications. Its versatility in chemical reactions makes it a valuable component in the production of various chemical products, including those used in the pharmaceutical, agrochemical, and materials science industries.
Used in Research and Development:
Due to its unique structure and properties, 2-Amino-3-bromobenzoic acid is often employed in research and development settings. Scientists and researchers use it to study various biological and chemical processes, as well as to develop new methods and techniques for synthesizing complex molecules.

InChI:InChI=1/C7H6BrNO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,9H2,(H,10,11)/p-1

Upstream product

• 20780-74-9 7-bromoisatin 
• 116529-61-4 3-bromo-2-nitrobenzoic acid 
• 861791-77-7 2-acetylamino-3-bromo-benzoic acid 
• 7647-01-0 hydrogenchloride 
• 118-92-3 anthranilic acid 
• 89-52-1 o-acetylamino-benzoic acid 
• 101080-38-0 N-(2-bromo-phenyl)-2-[(E)-hydroxyimino]acetamine 
• 104670-74-8 methyl 2-amino-3-bromobenzoate 
• 615-36-1 2-bromoaniline 
• 101080-38-0 N-(2-bromophenyl)-2-isonitrosoacetanilide 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 104670-74-8 methyl 2-amino-3-bromobenzoate 
• 603-78-1 2,3-dibromobenzoic acid 
• 118-92-3 anthranilic acid 
• 71478-56-3 8-bromo-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 67090-35-1 2-benzyl 8-bromo benzoxazinone 
• 21192-04-1 1-Brom-triptycen 
• 331646-99-2 8-bromoquinazoline-2,4-diol 
• 74461-36-2 3-(1H-Benzoimidazol-2-ylmethyl)-8-bromo-2-phenyl-3H-quinazolin-4-one 
• 74461-39-5 3-[1-(1H-Benzoimidazol-2-yl)-ethyl]-8-bromo-2-phenyl-3H-quinazolin-4-one 
• 1186037-92-2 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-7-carboxylic acid 
• 1186040-12-9 methyl 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-7-carboxylate 
• 1260015-16-4 C₃₂H₁₉Br 
• 1263413-81-5 8-bromo-2,3-dimethyl-3H-quinazolin-4-one 
• 1269467-18-6 methyl 4-(3-ethynylphenylamino)thieno[3,2-c]quinoline-6-carboxylate 

Relevant articles and documents

Bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof

The invention discloses a bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof. The invention provides the bicyclic heteroaryl compound with PAR4 antagonistic activity,and the bicyclic heteroaryl compound has remarkable antagonistic activity on PAR4 in an in-vitro anti-platelet aggregation experiment, so that platelet aggregation is effectively inhibited, and the bicyclic heteroaryl compound can be used for preparing medicines for preventing or treating various thromboembolic diseases.

Br?nsted Acid-Catalyzed Asymmetric Ring-Closing Alkylation of Inert N-substituted Pyrroles with α, β-Unsaturated Ketones

A Chiral Br?nsted acid catalyzed asymmetric intramolecular ring-closing alkylation of inert pyrroles with α, β-unsaturated ketones has been developed. This approach gave a wide range of 4-phenyl-4,5-dihydro-6H-benzo[f]pyrrolo[1,2-a]azepin-6-ones in high yields with good enantioselectivities under mild reaction conditions. (Figure presented.).

A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase-Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations

Arylhalides are important building blocks in many fine chemicals, pharmaceuticals and agrochemicals, and there has been increasing interest in the development of more "green" halogenation methods based on enzyme catalysis. However, the screening and development of new enzymes for biohalogenation has been hampered by a lack of high-throughput screening methods. Described herein is the development of a colorimetric assay for detecting both chemical and enzymatic arylamine halogenation reactions in an aqueous environment. The assay is based on the unique UV/Vis spectrum created by the formation of an ortho-benzoquinone-amine adduct, which is produced by the peroxidase-catalysed benzoquinone generation, followed by Michael addition of either a halogenated or non-halogenated arylamine. This assay is sensitive, rapid and amenable to high-throughput screening platforms. We have also shown this assay to be easily coupled to a flavin-dependent halogenase, which currently lacks any convenient colorimetric assay, in a "one-pot" workflow.