20809-97-6

Basic information

• Product Name: diethyl (4-methylphenyl)phosphoramidate
• CAS NO: 20809-97-6
• Molecular Formula: C₁₁H₁₈NO₃P
• Molecular Weight: 243.2393
• Mol File: 20809-97-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 308.2°C at 760 mmHg
• Flash Point: 140.2°C
• Density: 1.149g/cm³
• Vapor Pressure: 0.00069mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: diethyl (4-methylphenyl)phosphoramidate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-methylphenyl)phosphoramidate(20809-97-6)
• EPA Substance Registry System: diethyl (4-methylphenyl)phosphoramidate(20809-97-6)

Safety Data

• Hazardous Substances Data: 20809-97-6(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 33862-27-0 N-(4-methylphenyl) phosphoramidic dichloride 
• 18476-29-4 triethyl N-(4-tolyl)-phosphorimidate 
• 99-99-0 1-methyl-4-nitrobenzene 
• 122-52-1 triethyl phosphite 
• 6374-26-1 diethyl phosphorisothiocyanatidate 
• 106-49-0 p-toluidine 
• 762-04-9 phosphonic acid diethyl ester 
• 762-04-9 Diethyl phosphonate 
• 2101-86-2 p-methylazidobenzene 

Downstream Products

• 1266570-24-4 diethyl 1-(4-fluorophenyl)-3,3-diphenylpropa-1,2-dienyl(p-tolyl)phosphoramidate 
• 1266570-25-5 C₃₄H₃₆NO₃P 
• 1266570-30-2 diethyl 3-(4-chlorophenyl)-3-(4-methoxyphenyl)-1-phenylpropa-1,2-dienyl(p-tolyl)phosphoramidate 
• 1266570-17-5 diethyl p-tolyl(1,3,3-triphenylpropa-1,2-dienyl)phosphoramidate 
• 1266570-38-0 1,3,4,9,9-pentaphenyl-2-p-tolyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-43-7 4,9,9-triphenyl-1,2,3-tri-p-tolyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-31-3 diethyl 2-(9H-fluoren-9-ylidene)-1-phenylvinyl(p-tolyl)phosphoramidate 
• 1266570-27-7 diethyl 3,3-bis(4-methoxyphenyl)-1-phenylpropa-1,2-dienyl(p-tolyl)phosphoramidate 
• 1266570-45-9 1,3-bis(4-bromophenyl)-4,9,9-triphenyl-2-p-tolyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 

Relevant articles and documents

Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates

A practical phosphorylation for generating organophosphates and phosphoramidatesviaelectrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.

Trichloroisocyanuric Acid as an Efficient Reagent for the Synthesis of Phosphoroamidates via Atherton-Todd Reaction under Base-Free Conditions

A simple, efficient, and novel method is developed for the synthesis of phosphoroamidates via an Atherton-Todd coupling reaction of amines with dialkyl H-phosphite using trichloroisocyanuric acid as an efficient and safe reagent. Treatment of amines with dialkyl H-phosphite and trichloroisocyanuric acid under base-free conditions gives phosphoroamidates in moderate to good yields. The reaction proceeded effectively to afford the corresponding phosphoroamidates via a dehydrogenative coupling of H-phosphonates with amines. This method is easy, rapid, and good-yielding for the synthesis of phosphoroamidates.

Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday

A simple and efficient method is presented for the synthesis of phosphoroamidates in moderate to good yield via the Atherton-Todd coupling of primary amines with H-dialkyl phosphites using Fe3O4@MgO nanoparticles as a recyclable catalyst.