2101-86-2

Basic information

• Product Name: NISTC2101862
• Synonyms: NISTC2101862;1-Methyl-4-azidobenzene;4-Azidotoluene;4-Methyl-1-azidobenzene;4-Methylphenyl azide;p-Methylphenyl azide;4-Azidotoluene solution;4-Azidotoluene solution ~0.5 M in tert-butyl methyl ether, >=95.0% (HPLC)
• CAS NO: 2101-86-2
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.1506
• Mol File: 2101-86-2.mol
• Article Data: 159

Chemical Properties

• Melting Point: -29°C
• Boiling Point: 235.67°C (rough estimate)
• Flash Point: -33℃
• Appearance: /
• Density: 1.0527
• Refractive Index: 1.5341 (estimate)
• Storage Temp.: ?20°C
• BRN: 1841411
• CAS DataBase Reference: NISTC2101862(CAS DataBase Reference)
• NIST Chemistry Reference: NISTC2101862(2101-86-2)
• EPA Substance Registry System: NISTC2101862(2101-86-2)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 16
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 2101-86-2(Hazardous Substances Data)

Usage

Description

NISTC2101862, also known as 4-Azidotoluene, is an aromatic azide that is primarily utilized in chemical reactions, specifically in copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). NISTC2101862 is known for its ability to facilitate the functionalization of various molecules, making it a valuable tool in the field of chemistry and material science.

Uses

Used in Chemical Synthesis:
NISTC2101862 is used as a reactant for the functionalization of boron subphthalocyanines with a terminal acetylene functionality. This is achieved through copper(I)-catalyzed azide-alkyne cycloaddition in the presence of Hunig's base, which allows for the creation of new compounds with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, NISTC2101862 plays a crucial role in the development of novel drug delivery systems. Its use in CuAAC reactions enables the synthesis of various organic and metallic nanoparticles, which can be employed as carriers for the delivery of therapeutic agents. This improves the bioavailability and therapeutic outcomes of drugs, particularly in the treatment of cancer.
Used in Material Science:
NISTC2101862 is also used in material science for the synthesis of new materials with specific properties. The functionalization of molecules using CuAAC reactions involving 4-azidotoluene allows for the creation of materials with tailored characteristics, such as improved mechanical strength, thermal stability, or chemical resistance. These materials can be used in various applications, including electronics, aerospace, and automotive industries.

InChI:InChI=1/C7H7N3/c1-6-2-4-7(5-3-6)9-10-8/h2-5H,1H3

Upstream product

• 3144-09-0 methanesulfonamide 
• 2028-84-4 p-methylbenzenediazonium chloride 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 3076-56-0 p-tolyllead triacetate 
• 106-49-0 p-toluidine 
• 102127-66-2 1-nitroso-3-(4-pyridylmethyl)-1-(4-tolyl)urea 
• 32785-43-6 p-tolyl-pentazole 
• 539-44-6 N-4-methylphenylhydrazine 
• 14106-51-5 p-tolyl-diazenecarboxylic acid amide 
• 7334-78-3 p-CH₃C₆H₄NNN(NH₂)C₆H₅ 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 122099-10-9 1-azido-2-iodo-4-methyl-benzene 
• 106-38-7 para-bromotoluene 

Downstream Products

• 23438-17-7 4-methoxy-4-methylcyclohexa-2,5-dien-1-one 
• 20667-76-9 1-methyl-3-(p-tolyl)triaz-1-ene 
• 92245-76-6 4-(2-methyl-5-nitro-benzyl)-aniline 
• 855650-44-1 diazomalonic acid ethyl ester-p-toluidide 
• 622-74-2 N-phenyl-N'-p-tolyl-triazene 
• 23438-23-5 4-hydroxy-4-methyl-cyclohexa-2,5-dienone 
• 95-71-6 2-methylbenzene-1,4-diol 
• 108840-87-5 4-phenyl-1-(p-tolyl)-1H-1,2,3-triazol-5-amine 
• 72680-08-1 ethyl 5-amino-1-p-tolyl-1H-1,2,3-triazole-4-carboxylate 
• 2327-67-5 N-(p-tolyl)-P,P,P-triphenylphosphine imide 
• 29813-87-4 N-(4-hydroxyphenyl)-p-toluidine 
• 66172-26-7 2-p-tolyl-5-(2,2,2-trifluoro-1-trifluoromethyl-ethylidene)-2,5-dihydro-[1,2,3,4]thiatriazole 
• 20113-27-3 tributyl-N-(p-tolyl)-phosphorimidate 
• 19946-86-2 C₁₅H₂₇ClN₃P 

Relevant articles and documents

Cu(i)-catalyzed microwave-assisted synthesis of 1,2,3-triazole linked with 4-thiazolidinones: A one-pot sequential approach

A novel copper(i) catalyzed, microwave-assisted one-pot, four-component sequential reaction between a propargyloxybenzaldehyde, a substituted phenyl azide, a substituted aniline and thioglycolic acid has been developed for the synthesis of 3-phenyl-2-[4-{

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A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates

It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol

Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof

The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a

Selective CDK4/6 inhibition of novel 1,2,3-triazole tethered acridinedione derivatives induces G1/S cell cycle transition arrest via Rb phosphorylation blockade in breast cancer models

CDK4 & CDK6 are essential regulators of initial cell cycle phases and are always considered an exciting choice for anti-cancer therapy. In the present study, we presented the structure-based rational design & synthesis of a new class of 1,2,3-triazole tet