23438-17-7

Basic information

• Product Name: 2,5-Cyclohexadien-1-one, 4-methoxy-4-methyl-
• CAS NO: 23438-17-7
• Molecular Formula: C8H10O2
• Molecular Weight: 138.166
• Mol File: 23438-17-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2,5-Cyclohexadien-1-one, 4-methoxy-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Cyclohexadien-1-one, 4-methoxy-4-methyl-(23438-17-7)
• EPA Substance Registry System: 2,5-Cyclohexadien-1-one, 4-methoxy-4-methyl-(23438-17-7)

Safety Data

• Hazardous Substances Data: 23438-17-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 2101-86-2 p-methylazidobenzene 
• 89345-78-8 C₁₀H₁₃NO₄S 
• 27451-21-4 N-hydroxy-N-(p-tolyl)acetamide 
• 106-44-5 p-cresol 
• 104-93-8 p-methylanizole 
• 23438-13-3 8-methoxy-3,3,8-trimethyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-2-one 
• 89345-80-2 4-O-Methyl-4-methyl-p-benzoquinol N-acetylimine 
• 110391-89-4 8-Methoxy-8-methyl-1,4-dioxa-spiro[4.5]deca-6,9-diene 

Downstream Products

• 129930-84-3 1,4-Dimethyl-4-hydroxy-2,5-cyclohexadienyl methyl ether 
• 74894-53-4 anti-4-methoxy-1,4-dimethyl-2,5-cyclohexadienol 
• 74894-52-3 (Z)-4-methoxy-1,4-dimethylcyclohexa-2,5-dienol 
• 86255-22-3 (1-Hydroxy-4-methoxy-4-methyl-cyclohexa-2,5-dienyl)-acetic acid methyl ester 
• 1188925-33-8 C₁₁H₁₀O₃ 
• 827-60-1 1-(4-methylphenyl)-1H-pyrrole 
• 828248-59-5 (1R,4S,4aR,8R,8aS)-8-methoxy-8-methyl-4,4a,8,8a-tetrahydro-1,4-methanonaphthalen-5(1H)-one 

Relevant articles and documents

Site-selective 1,3-double functionalization of arenes using: Para -quinol, C-N, and C-C/C-P three-component coupling

A catalytic and site-selective approach has been demonstrated for dual functionalization of arenes via cross-coupling reactions of p-quinols with amines and isocyanides/phosphites. The strategy enables the production of a series of 3-amino-benzamides and

Site-Selective Iron(III) Chloride-Catalyzed Arylation of 4-Aryl-4-methoxy-2,5-cyclohexadienones for the Synthesis of Polyarylated Phenols

The iron(III) chloride-catalyzed Friedel–Crafts arylation of 4-aryl-4-methoxy-2,5-cyclohexadienones, which were easily prepared by the phenyliodine(III) diacetate (PIDA)-mediated oxidation of 4-arylphenols in methanol, proceeded site-selectively to form meta-terphenyl (2,4-diarylphenol) derivatives in good yields. The subsequent PIDA-mediated oxidation and iron(III) chloride-catalyzed Friedel–Crafts arylation of the resulting products gave the corresponding 2,4,6-triarylphenol derivatives. The present method provides useful highly substituted polyarylated compounds. (Figure presented.).

A detour route for meta functionalization of phenols

Cyclohexadienones participate in a two-step procedure, a Michael addition followed by aromatization, providing hitherto difficult-to-synthesize meta-functionalized phenol derivatives in good yield. Application of the developed approach is exemplified by synthesizing C-aryl acetophenones, C-aryl glycines, and elemicin - an allylphenol natural product. Georg Thieme Verlag Stuttgart · New York.