208186-84-9

Basic information

• Product Name: 2-CHLORO-4-FLUOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0289;TIMTEC-BB SBB006607;2-CHLORO-4-FLUOROBENZYL ALCOHOL 97%;2-Chloro-4-fluorobenzylalcohol97%;2-Chloro-4-fluorobenzyl alcohol, 98+%;2-Chloro-4-fluorobenzyl alcohol,99%;(2-Chloro-4-fluorophenyl)Methanol;2-CHLORO-4-FLUOROBENZYL ALCOHOL
• CAS NO: 208186-84-9
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohol;Alcohols;Chlorine Compounds;Fluorine Compounds
• Mol File: 208186-84-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 45-48 °C(lit.)
• Boiling Point: 160°C (rough estimate)
• Flash Point: 230 °F
• Appearance: /
• Density: 1.2780 (estimate)
• Vapor Pressure: 0.0315mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 13.54±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-FLUOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-FLUOROBENZYL ALCOHOL(208186-84-9)
• EPA Substance Registry System: 2-CHLORO-4-FLUOROBENZYL ALCOHOL(208186-84-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 208186-84-9(Hazardous Substances Data)

Usage

Chemical Properties

WHITE CRYSTALLINE POWDER

InChI:InChI=1/C7H6ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-3,10H,4H2

Upstream product

• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 

Downstream Products

• 881854-96-2 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde 
• 525570-29-0 4-(2-chloro-4-fluoro-benzyloxy)-3-methoxy-benzaldehyde 
• 219765-26-1 2-chloro-4-fluorobenzyl mesylate 
• 1013915-60-0 sodium 2-chloro-4-fluorobenzyloxymethyl trifluoroborate 
• 1258458-51-3 [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester 
• 1393724-19-0 (R)-3-(3-(4-(2-chloro-4-fluorobenzyloxy)phenyl)-2-((4,5-dimethoxy-2-nitrobenzyloxy)carbonylamino)propanamido)propanoic acid 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 69943-47-1 (2-chloro-4-fluorophenyl)(phenyl)methanone 
• 1620217-67-5 1-benzyl-2-chloro-4-fluorobenzene 

Relevant articles and documents

N-(Substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof

The invention relates to an N-(substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof, in particular to an N-(substituted sulfonyl)benzamide derivativeshown as general formula (I), preparation method thereof, medicinal salts of the derivative, and their application as therapeutics, especially as Nav1.7 inhibitors, wherein substituents in the general formula (I) shown in the description are defined the same as in the description.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

Sulfonamide compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.