2252-51-9Relevant articles and documents
Stepwise benzylic oxygenation via uranyl-photocatalysis
Hu, Deqing,Jiang, Xuefeng
supporting information, p. 124 - 129 (2022/01/19)
Stepwise oxygenation at the benzylic position (1°, 2°, 3°) of aromatic molecules was comprehensively established under ambient conditions via uranyl photocatalysis to produce carboxylic acids, ketones, and alcohols, respectively. The accuracy of the stepwise oxygenation was ensured by the tunability of catalytic activity in uranyl photocatalysis, which was adjusted by solvents and additives demonstrated through Stern–Volmer analysis. Hydrogen atom transfer between the benzylic position and the uranyl catalyst facilitated oxygenation, further confirmed by kinetic studies. Considerably improved efficiency of flow operation demonstrated the potential for industrial synthetic application.
2-chloro-4-fluorobenzoic acid and preparation method thereof
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Paragraph 0041-0042, (2017/04/03)
The invention discloses 2-chloro-4-fluorobenzoic acid and a preparation method thereof. With m-chloroaniline as a raw material, the method comprises the following steps: realizing amino protection through 2-(trimethylsilyl) ethoxymethyl chloride; realizing formylation through a Vilsmeier-Haack reaction; oxidizing to obtain carboxylic acid; performing hydrogenation reduction of nitro; and performing a fluorination reaction to obtain 2-chloro-4-fluorobenzoic acid. The pesticide intermediate 2-chloro-4-fluorobenzoic acid disclosed by the invention is easy to prepare and suitable for batch production; and moreover, by adopting the cheap m-chloroaniline as a raw material and the substances with low volatility and low toxicity in the preparation process and by controlling the types and addition amount of the catalyst and oxidant, the product yield is more than or equal to 85%.
INHIBITORS OF STEAROYL-COA DESATURASE
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, (2009/06/27)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.