886624-05-1

Basic information

• Product Name: 2-chloro-N-benzyl-4-fluorobenzamide
• Synonyms: 2-chloro-N-benzyl-4-fluorobenzamide
• CAS NO: 886624-05-1
• Molecular Weight: 263.699
• Mol File: 886624-05-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-benzyl-4-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-benzyl-4-fluorobenzamide(886624-05-1)
• EPA Substance Registry System: 2-chloro-N-benzyl-4-fluorobenzamide(886624-05-1)

Safety Data

• Hazardous Substances Data: 886624-05-1(Hazardous Substances Data)

Upstream product

• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 100-46-9 benzylamine 
• 21900-54-9 2-chloro-4-fluorobenzoyl chloride 

Downstream Products

• 1383572-73-3 N-benzyl-4-fluoro-2-hydroxybenzamide 

Relevant articles and documents

Practical Synthesis of Phenanthridinones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope to o-Chlorobenzamides

A highly efficient construction of phenanthridinone derivatives from o-halobenzamides was developed by using a phosphine-free palladium catalyst in N,N-dimethylacetamide. The domino reaction proceeds through a sequential C-C and C-N bond-formation process in one pot. This protocol exhibits broad substrate scope and affords a series of phenanthridinones in up to 93 % yield. Importantly, the protocol could also be applied for the less reactive o-chlorobenzamides. The approach constitutes the first example of the synthesis of phenanthridinones from this kind of substrate. Moreover, the success of a gram-scale reaction demonstrated that this operationally simple process is scalable.

Cu-catalyzed efficient synthetic methodology for ebselen and related se-N heterocycles

An efficient copper-catalyzed method for the synthesis of biologically important ebselen and related analogues containing a Se-N bond has been developed. This is the first report of a catalytic process of selenation and Se-N bond formation reaction. Copper-catalyzed reaction tolerates functional groups such as amides, hydroxyls, ethers, nitro, fluorides, and chlorides. The best results are obtained by using a combination of potassium carbonate as a base, iodo- or bromo-arylamide substrates, selenium powder, and copper iodide catalyst.