208331-49-1

Basic information

• Product Name: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-
• CAS NO: 208331-49-1
• Molecular Formula: C19H21F3OSi
• Molecular Weight: 350.456
• Mol File: 208331-49-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(208331-49-1)
• EPA Substance Registry System: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(208331-49-1)

Safety Data

• Hazardous Substances Data: 208331-49-1(Hazardous Substances Data)

Upstream product

• 614-47-1 1,3-diphenyl-propen-3-one 
• 289706-46-3 4-[2,2,2-trifluoro-1-(trimethylsilyloxy)ethyl]morpholine 
• 497937-79-8 N-trifluoromethanesulfinyl-O-trimethylsilylephedrine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 94-41-7 benzalacetophenone 
• 497937-77-6 N-trifluoroacetyl-O-trimethylsilylephedrine 
• 75-46-7 trifluoromethan 
• 1586-73-8 tris(trimethylsilyl)amine 

Downstream Products

• 208331-48-0 1-(trans)-phenylethenyl-1-phenyl-trifluoromethylcarbinol 

Relevant articles and documents

MgCl2-catalyzed trifluoromethylation of carbonyl compounds using (trifluoromethyl)trimethylsilane as the trifluoromethylating agent

Using (trifluoromethyl)trimethylsilane (TMSCF3) as the trifluoromethylating agent, MgCl2-catalyzed trifluoromethylation of carbonyl compounds proceeded readily at room temperature. In the presence of 10 mol% of MgCl2, a variety of carbonyl substrates such as aliphatic/aromatic aldehydes, acyclic/cyclic ketones and esters could be trifluoromethylated in DMF, giving the corresponding trimethylsilyl ethers (ketals) in up to 93% isolated yields. Trifluoromethylketones could be readily obtained after hydrolysis of the trimethylsilyl ketals. The reactions could tolerate air and moisture, and the use of oxygen and moisture-free conditions was not required.

Acid-promoted cyclization of 2,4-diaryl-1,1,1-trifluorobut-3-en-2-oles and their TMS-ethers into CF3-indenes

2,4-Diaryl-1,1,1-trifluorobut-3-en-2-oles and their TMS-ethers in H2SO4 at room temperature in just 2 min are quantitatively cyclized into 1-aryl-3-trifluoromethyl-1H-indenes. The reaction proceeds through an intermediate formation o

TTMPP-catalyzed trifluoromethylation of carbonyl compounds and imines with trifluoromethylsilane

A highly basic phosphine, tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP), catalyzes trifluoromethylation using trifluoromethyltrimethylsilane to give the corresponding trifluoromethylated products in good to high yields, with both carbonyl compounds and im