208512-45-2Relevant articles and documents
Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives
Springer, Dane M.,Luh, Bing-Yu,Goodrich, Jason,Bronson, Joanne J.
, p. 265 - 279 (2007/10/03)
Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.