307002-27-3

Basic information

• Product Name: diphenylmethyl (6R,7R)-7-[2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetamido]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Synonyms: diphenylmethyl (6R,7R)-7-[2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetamido]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS NO: 307002-27-3
• Molecular Weight: 817.211
• Mol File: 307002-27-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: diphenylmethyl (6R,7R)-7-[2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetamido]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diphenylmethyl (6R,7R)-7-[2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetamido]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(307002-27-3)
• EPA Substance Registry System: diphenylmethyl (6R,7R)-7-[2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetamido]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate(307002-27-3)

Safety Data

• Hazardous Substances Data: 307002-27-3(Hazardous Substances Data)

Upstream product

• 32609-05-5 2,4,5-trichloro-cinnamic acid 
• 307002-20-6 2-({4-[(1E)-2-{[2-(tert-butoxy)-2-oxoethyl]carbamoyl}eth-1-en-1-yl]-2,5-dichlorophenyl}sulfanyl)acetic acid 
• 79349-53-4 (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxyli acid diphenylmethyl ester hydrochloride 
• 636-30-6 2,4,5-trichloroaniline 
• 208512-45-2 (E)-3-(2,5-Dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid 
• 208512-74-7 dimethyl-thiocarbamic acid O-(2,5-dichloro-4-iodo-phenyl) ester 
• 208512-77-0 (2,5-dichloro-4-iodo-phenylsulfanyl)-acetic acid methyl ester 
• 208512-76-9 2,3-dichloro-4-iodothiophenol 
• 7145-82-6 2,4,5-trichloroiodobenzene 
• 7587-15-7 2,3-dichloro-4-iodophenol 
• 583-78-8 2,5-dichlorophenol 
• 208512-82-7 (6R,7R)-7-{2-[4-((E)-2-tert-Butoxycarbonyl-vinyl)-2,5-dichloro-phenylsulfanyl]-acetylamino}-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 208512-49-6 {4-[2-(tert-butoxycarbonylmethyl-carbamoyl)-vinyl]-2,5-dichloro-phenylsulfanyl}-acetic acid methyl ester 
• 208512-47-4 (E)-3-(2,5-Dichloro-4-methoxycarbonylmethylsulfanyl-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester 

Relevant articles and documents

Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives

Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.