20881-29-2

Basic information

• Product Name: α-Methylbenzenebutyric acid methyl ester
• Synonyms: 4-Phenyl-2-methylbutanoic acid methyl ester;α-Methylbenzenebutanoic acid methyl ester;α-Methylbenzenebutyric acid methyl ester;4-Phenylpentanoic acid methyl ester;4-Phenylvaleric acid methyl ester
• CAS NO: 20881-29-2
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• Mol File: 20881-29-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Methylbenzenebutyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: α-Methylbenzenebutyric acid methyl ester(20881-29-2)
• EPA Substance Registry System: α-Methylbenzenebutyric acid methyl ester(20881-29-2)

Safety Data

• Hazardous Substances Data: 20881-29-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 16433-43-5 4-phenyl-1-pentanoic acid 
• 7210-42-6 5-methyl-5-phenyl-dihydro-furan-2-one 
• 591-80-0 pent-4-enoic acid 
• 71-43-2 benzene 
• 40474-22-4 cis/trans-2-Methyl-2-phenyl-1-cyclopropancarbonsaeure-methylester 
• 93863-05-9 4-phenylpent-4-enoic acid methyl ester 
• 14273-86-0 methyl 5-chloropentanoate 
• 64252-49-9 (E)-4-Phenyl-2-pentensaeure-methylester 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 2365-48-2 Methyl thioglycolate 
• 98-83-9 isopropenylbenzene 

Downstream Products

• 16433-43-5 4-phenyl-1-pentanoic acid 
• 51193-79-4 1,1-dimethyl-4-phenylpentanol 
• 134953-17-6 methyl 4-(4-acetylphenyl)pentanoate 
• 40463-15-8 1,1,4-trimethyl-tetralin 
• 30368-31-1 8-Phenylnonansaeuremethylester 

Relevant articles and documents

N-Heterocyclic Carbene Catalyzed γ-Dihalomethylenation of Enals by Single-Electron Transfer

An N-heterocyclic carbene (NHC) catalyzed dihalomethylenation of enals is described. It is a rare example of merging NHC catalysis with single-electron chemistry, a challenging topic with limited previous success. The versatile carbon-centered trihalomethyl radicals have been demonstrated, for the first time, to be compatible with an NHC-bound intermediate, thus leading to efficient and regioselective intermolecular C?C bond formation. The mild process provides straightforward access to unsaturated δ,δ-dihalo esters.

Two-way homologation of aliphatic aldehydes: Both one-carbon shortening and lengthening via the same intermediate

Aliphatic aldehydes can be homologated to both one-carbon shorter and one-carbon longer homologous carbonyl compounds through the 2–4 steps of reactions via the same intermediates, β,γ-unsaturated α-nitrosulfones, prepared from the proline-catalyzed sequential reactions of several aliphatic aldehydes with phenylsulfonylnitromethane. While the oxidative cleavage of the key intermediates gave one-carbon less homologous carbonyl compounds, the reduction of the same key intermediates followed by an oxidation produced one-carbon more homologous carbonyl compounds.

A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes

An intermolecular reductive C-C coupling of electrophilic alkyl radicals and alkenes has been developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of triethyl phosphite and radical initiator. A wide range of alkenes, including styrenes, and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to access electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.