208941-54-2

Basic information

• Product Name: (2'-METHOXYBIPHENYL-3-YL)-METHANOL
• Synonyms: AKOS BAR-1808;(2'-METHOXY[1,1'-BIPHENYL]-3-YL)METHANOL;(2'-METHOXYBIPHENYL-3-YL)-METHANOL;3-(2-Methoxyphenyl)benzyl alcohol;[3-(2-methoxyphenyl)phenyl]methanol
• CAS NO: 208941-54-2
• Molecular Formula: C14H14O2
• Molecular Weight: 214.26
• Product Categories: pharmacetical
• Mol File: 208941-54-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2'-METHOXYBIPHENYL-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2'-METHOXYBIPHENYL-3-YL)-METHANOL(208941-54-2)
• EPA Substance Registry System: (2'-METHOXYBIPHENYL-3-YL)-METHANOL(208941-54-2)

Safety Data

• Hazardous Substances Data: 208941-54-2(Hazardous Substances Data)

Usage

Description

(2'-METHOXYBIPHENYL-3-YL)-METHANOL, with the chemical formula C14H14O2, is a white to off-white crystalline solid. It is insoluble in water but soluble in organic solvents, making it a versatile compound for various applications.
Used in Pharmaceutical Industry:
(2'-METHOXYBIPHENYL-3-YL)-METHANOL is used as a building block for the synthesis of other organic compounds, particularly in the pharmaceutical industry. Its unique structure allows it to be a key component in the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, (2'-METHOXYBIPHENYL-3-YL)-METHANOL is also utilized as a building block in the synthesis of organic compounds. Its properties make it suitable for the creation of new agrochemicals, potentially enhancing crop protection and yield.
Used in Organic Chemistry Research:
(2'-METHOXYBIPHENYL-3-YL)-METHANOL is used as a reagent in organic chemistry reactions, specifically in the formation of carbon-carbon bonds. This contributes to the advancement of organic chemistry by enabling the synthesis of complex molecules.
Used in Research and Development:
(2'-METHOXYBIPHENYL-3-YL)-METHANOL has potential applications in research and development, particularly in the study of organic compounds and their properties. Its versatility and solubility in organic solvents make it a valuable compound for scientific exploration and innovation.

Upstream product

• 5720-06-9 2-Methoxyphenylboronic acid 
• 208941-39-3 4-(4-Carboxy-butoxy)-benzoic acid 3-iodo-benzyl ester 
• 86487-17-4 2-tri-n-butylstannylanisole 
• 35005-21-1 4-(4-Carboxy-butoxy)-benzoic acid 
• 578-57-4 2-bromoanisole 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 

Relevant articles and documents

Development of unimolecular tetrakis(piperidin-4-ol) as a ligand for Suzuki-Miyaura cross-coupling reactions: Synthesis of incrustoporin and preclamol

Abstract A domino aza-Cope/aza-Prins cascade enabled the synthesis of a new class of 4-hydroxypiperidine-appended mono, bis, tris, and tetrakis unimolecular compounds that served as efficient ligands to catalyze Suzuki-Miyaura cross-coupling reactions under aerobic conditions. Various biaryls, terphenyls, and heterocyclic biphenyls were obtained in good to excellent yields. The ligands were also capable of catalyzing the Heck-Mizoroki reaction. As an application, the Suzuki-Miyaura coupling reaction was used in the synthesis of incrustoporin, its analogs, and the drug molecule preclamol. A domino aza-Cope/aza-Prins cascade enabled the synthesis of a new class of 4-hydroxypiperidine-appended mono-, bis-, tris-, and tetrakis-unimolecular compounds that served as efficient ligands to catalyze Suzuki-Miyaura cross-coupling reactions under aerobic conditions. Various biaryls, terphenyls, and heterocyclic biphenyls were obtained in good to excellent yields.

Pd-mediated C-C and C-S bond formation on solid support: A scope and limitations study

The scope and limitations of Pd(0)-mediated coupling reactions between aromatic halides linked to a polystyrene resin and boronic acid derivatives (Suzuki coupling), aromatic and vinylic tin compounds (Stille coupling), as well as thiols are reported. For all reactions, conditions were optimized and evaluated with various reagents. In many cases, upon cleavage from the solid support, products were obtained in excellent yields. In most cases, the optimized reaction conditions are superior to those previously reported in the literature.