20943-60-6

Basic information

• Product Name: ethyl 2-(ethylamino)-2-oxoacetate
• Synonyms: ethyl 2-(ethylamino)-2-oxoacetate;Ethyl (ethylamino)(oxo)acetate
• CAS NO: 20943-60-6
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.16
• Mol File: 20943-60-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(ethylamino)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(ethylamino)-2-oxoacetate(20943-60-6)
• EPA Substance Registry System: ethyl 2-(ethylamino)-2-oxoacetate(20943-60-6)

Safety Data

• Hazardous Substances Data: 20943-60-6(Hazardous Substances Data)

Usage

Description

Ethyl 2-(ethylamino)-2-oxoacetate, also known as Ethyl N-ethyloxamate, is an organic compound with the molecular formula C6H11NO3. It is a derivative of oxamic acid and features an ethyl group attached to the nitrogen atom. ethyl 2-(ethylamino)-2-oxoacetate is characterized by its potential reactivity and utility in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(ethylamino)-2-oxoacetate is used as a key intermediate in the synthesis of Kinase 2 (GRK2) Inhibitors for the treatment of heart failure. These inhibitors play a crucial role in regulating the activity of GRK2, which is involved in the development and progression of heart failure. By targeting GRK2, these inhibitors can help improve the overall management and treatment outcomes for patients suffering from this condition.

Upstream product

• 75-04-7 ethylamine 
• 95-92-1 oxalic acid diethyl ester 
• 216959-38-5 (tert-butoxycarbonyl-ethyl-amino)-oxo-acetic acid ethyl ester 
• 7732-18-5 water 
• 557-66-4 ethanamine hydrochloride 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 75235-35-7 2-(ethylamino)-2-oxoacetic acid 
• 357268-25-8 N-ethyl-N'-phenyl-oxalamide 
• 82755-96-2 ethyl 1H-benzo[d]imidazole-2-carboxylate 
• 64-17-5 ethanol 

Relevant articles and documents

Oxamic acid analogues as LDH-C4-specific competitive inhibitors

We performed kinetic studies to determine whether oxamate analogues are selective inhibitors of LDH-C4, owing to their potential usefulness in fertility control and treatment of some cancers. These substances were shown to be competitive inhibitors of LDH isozymes and are able to discriminate among subtle differences that differentiate the active sites of LDH-A4, LDH-B4 and LDH-C4. N-Ethyl oxamate was the most potent inhibitor showing the highest affinity for LDH-C4. However, N-propyl oxamate was the most selective inhibitor showing a high degree of selectivity towards LDH-C4. Non-polar four carbon atoms chains, linear or branched, dramatically diminished the affinity and selectivity towards LDH-C4. N-Propyl oxamate significantly reduced ATP levels, capacitation and mouse sperm motility, in line with results shown by others, suggesting that LDH-C4 plays an essential role in mouse fertility.

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)

ARYLPYRAZINONE DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES

The present invention relates to arylpyrazinone derivatives of formula (I), wherein R1, R2, R3 and A are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the