209627-36-1 Usage
Description
(2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol is a chiral silyl-protected pyrrolidine derivative featuring a pyrrolidine ring with a tert-butyldiphenylsilyl group attached to the oxygen atom, forming a silyl ether. (2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol has an S configuration at the second carbon atom and is utilized as a reagent or intermediate in organic synthesis, particularly for the preparation of other pyrrolidine derivatives. The tert-butyldiphenylsilyl group acts as a protective group, enabling selective manipulation of the pyrrolidine ring during chemical reactions. (2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol holds potential applications in medicinal chemistry, materials science, and other areas of organic chemistry.
Uses
Used in Organic Synthesis:
(2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol is used as a reagent or intermediate for the synthesis of other pyrrolidine derivatives, providing a versatile building block for the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol is utilized for the development of pharmaceutical compounds, taking advantage of its chiral properties and protective silyl group to create enantiomerically pure drugs with desired biological activities.
Used in Materials Science:
(2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol is employed in materials science for the design and synthesis of novel materials with specific properties, such as chiral polymers or other functional materials, leveraging its unique structural features and reactivity.
Used in Protective Group Chemistry:
The tert-butyldiphenylsilyl group in (2S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)idinepyrrol serves as a protective group, allowing chemists to selectively manipulate the pyrrolidine ring during chemical reactions. This selective protection is crucial in complex organic synthesis, where the preservation of specific functional groups is necessary to achieve the desired final product.
Check Digit Verification of cas no
The CAS Registry Mumber 209627-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,6,2 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 209627-36:
(8*2)+(7*0)+(6*9)+(5*6)+(4*2)+(3*7)+(2*3)+(1*6)=141
141 % 10 = 1
So 209627-36-1 is a valid CAS Registry Number.
209627-36-1Relevant articles and documents
COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS
-
Paragraph 00364-00370, (2021/10/15)
Bifunctional compounds, which find utility as modulators of Kirsten ras sarcoma protein (KRas or KRAS), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the Von Hippel-Lindau E3 ubiquitin ligase and on the other end a moiety which binds KRas, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The heterobifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PLATELET AGGREGATION
-
Paragraph 00195, (2017/05/10)
The present invention provides compounds of Formula I: wherein Y, AA, W, R3, R2, R4, R5, R6, R7, X1, X2, X3, X4 and X5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug or esters or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
Transfer of 1-alkenyl groups between secondary amines. Relative stability and reactivity of enamines from popular organocatalysts
Carneros, Hector,Sanchez, Dani,Vilarrasa, Jaume
, p. 2900 - 2903 (2014/06/23)
Enamines from 3-methylbutanal and several Pro- and Phe-derived secondary amines were prepared in DMSO-d6, CD3CN, and CDCl 3. For the first time, the relative thermodynamic stabilities of these and other enamines were compared, and rapid exchanges of 1-alkenyl groups were demonstrated. Competition experiments showed that the most favored enamines (without significant steric inhibition of resonance) react more rapidly with electrophiles.
