209731-54-4Relevant articles and documents
OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS
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, (2008/06/13)
The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula (I), or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O or S and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
Isoxazolines and Isoxazoles as Factor Xa inhibitors
Pruitt, James R.,Pinto, Donald J.,Estrella, Melissa J.,Bostrom, Lori L.,Knabb, Robert M.,Wong, Pancras C.,Wright, Matthew R.,Wexler, Ruth R.
, p. 685 - 689 (2007/10/03)
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.