41051-15-4

Basic information

• Product Name: Methyl 4-methoxyacetoacetate
• Synonyms: 4-methoxy-3-oxo-butanoicacimethylester;Butanoic acid, 4-methoxy-3-oxo-, methyl ester;Methyl methoxyacetoacetate;METHYL 4-METHOXYACETOACETATE;METHYL 4-METHOXYACETOXYACETATE;METHYL 4-METHOXY-3-OXO-BUTANOATE;4-METHOXYACETOACETIC ACID METHYL ESTER;methyl 4-methoxy-3-oxobutyrate
• CAS NO: 41051-15-4
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.14
• EINECS: 255-188-9
• Product Categories: Acetics acid and esters;C6 to C7;Carbonyl Compounds;Esters
• Mol File: 41051-15-4.mol
• Article Data: 20

Chemical Properties

• Melting Point: -80℃
• Boiling Point: 89 °C8.5 mm Hg(lit.)
• Flash Point: 193 °F
• Appearance: colorless to yellow liquid
• Density: 1.129 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: n20/D 1.431(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.88±0.46(Predicted)
• BRN: 1761215
• CAS DataBase Reference: Methyl 4-methoxyacetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-methoxyacetoacetate(41051-15-4)
• EPA Substance Registry System: Methyl 4-methoxyacetoacetate(41051-15-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 41051-15-4(Hazardous Substances Data)

Usage

Description

Methyl 4-methoxyacetoacetate is an organic compound that exists as a colorless to yellow liquid. It is a versatile reactant in various chemical reactions and synthesis processes, making it a valuable component in the field of organic chemistry.

Uses

Used in Chemical Synthesis:
Methyl 4-methoxyacetoacetate is used as a reactant for the formation of an abiotic porphyrinogen in aqueous solution. This application highlights its utility in the synthesis of complex organic molecules and its potential role in the study of biological processes.
Used in Pharmaceutical Industry:
Methyl 4-methoxyacetoacetate is used as a key component in the generation of a small focused library of diversely functionalized dihydropyrimidine derivatives. This is achieved through a one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes, and (thio)ureas. The resulting dihydropyrimidine derivatives have potential applications in the development of new pharmaceuticals, particularly in the treatment of various diseases and conditions.

InChI:InChI=1/C6H10O4/c1-9-4-5(7)3-6(8)10-2/h3-4H2,1-2H3

Upstream product

• 6290-49-9 methyl methoxyacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 17790-81-7 methyl 4-bromo-3-oxobutanoate 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 32807-28-6 Methyl 4-chloroacetoacetate 
• 382141-76-6 methyl 3-hydroxy-4-methoxybutanoate 
• 68665-45-2 4-methoxy-3-oxobutanoic acid 
• 107-03-9 1-thiopropane 
• 141-97-9 ethyl acetoacetate 
• 38330-80-2 monomethyl monopotassium malonate 
• 31059-08-2 1-(1H-imidazol-1-yl)-2-methoxyethanone 
• 105-45-3 acetoacetic acid methyl ester 
• 130895-62-4 methyl 2,4-dimethoxyacetoacetate 

Downstream Products

• 494202-82-3 2-amino-6-methoxymethyl-3H-pyrimidin-4-one 
• 104784-20-5 2-(2-Methoxy-acetyl)-4,5-dimethyl-hex-4-enoic acid methyl ester 
• 133902-69-9 4-methoxycarbonyl-5-methoxymethyl-1-phenyl-1,2,3-triazole 
• 192574-28-0 5-methoxycarbonyl-4-methoxymethyl-1,2,3,6-tetrahydro-2-oxo-6-(3,4-difluorophenyl)-pyrimidine 
• 252002-09-8 5-methoxycarbonyl-4-methoxymethyl-2-oxo-1,2,3,6-tetrahydro-6-(3,4,5-trifluorophenyl)pyrimidine 
• 252002-09-8 (+)-5-methoxycarbonyl-4-methoxymethyl-2-oxo-1,2,3,6-tetrahydro-6-(3,4,5-trifluorophenyl)pyrimidine 
• 209731-54-4 3-(3-cyanophenyl)-5-methoxymethyl-4-carbomethoxyisoxazole 
• 127958-19-4 4-(methoxymethyl)-2-phenylpyrimidine 
• 218430-63-8 (S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid methyl ester 
• 220497-99-4 (S)-4-(3,4-difluorophenyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-2-oxo-5-pyrimidinecarboxylic acid 
• 153862-94-3 4-Methoxy-3-oxo-2-(p-tolyl-hydrazono)-butyric acid methyl ester 
• 153862-92-1 2-[(4-Chloro-phenyl)-hydrazono]-4-methoxy-3-oxo-butyric acid methyl ester 
• 153862-99-8 4-Methoxy-2-[(4-nitro-phenyl)-hydrazono]-3-oxo-butyric acid methyl ester 

Relevant articles and documents

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Preparation method of 4-alkoxyacetoacetate compound

The invention discloses a preparation method of a 4-alkoxyacetoacetate compound, and the method comprises the following steps: reacting a compound I with a first alkali in a first solvent to obtain anintermediate II; reacting the intermediate II obtained in the step (1) with a second alkali in a second solvent to obtain an intermediate III; reacting the intermediate III obtained in the step (2) in an aqueous solution of acid to obtain a product IV, namely the 4-alkoxyacetoacetate compound, wherein X is chlorine, bromine or iodine; wherein R is a C1-C4 alkyl group and a derivative thereof. Thepreparation method provided by the invention has the advantages of simple steps, mild conditions, environmental friendliness, cheap and easily available raw materials, stable supply and low cost, andcreates favorable conditions for reducing the raw material cost of dolutegravir.

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.