209861-01-8

Basic information

• Product Name: TF-HF
• Synonyms: TF-HF;2H-Cyclopenta[b]furan-2-one, 4-[(1E)-3,3-difluoro-4-phenoxy-1-butenyl]hexahydro-5-hydroxy-, (3aR,4R,5R,6aS)-;(3AR,4R,5R,6aS)-4-((E)-3,3-Difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]fu;(3aR,4R,5R,6aS)-4-((E)-3,3-Difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one;2H-Cyclopenta[b]furan-2-one, 4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-5-hydroxy-, (3aR,4R,5R,6aS)-;(3aR,4R,5R,6aS)-4-((1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl)hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-4-[(1E)-3,3-Difluoro-4-phenoxy-1-butenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-one;(3AR,4R,5R,6aS)-4-((E)-3,3-Difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b
• CAS NO: 209861-01-8
• Molecular Formula: C₁₇H₁₈F₂O₄
• Molecular Weight: 324.3192264
• Mol File: 209861-01-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 484.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.355±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.19±0.40(Predicted)
• CAS DataBase Reference: TF-HF(CAS DataBase Reference)
• NIST Chemistry Reference: TF-HF(209861-01-8)
• EPA Substance Registry System: TF-HF(209861-01-8)

Safety Data

• Hazardous Substances Data: 209861-01-8(Hazardous Substances Data)

Usage

General Description

TF-HF, also known as Tetrafluorohydrazine, is a chemical compound with the molecular formula N2F4. It is a colorless, toxic gas that is highly reactive and flammable. TF-HF is used as a rocket fuel and as a chemical intermediate in the production of pharmaceuticals and agricultural chemicals. It is also used as a rocket propellant and as a precursor to other fluorine-containing compounds. TF-HF is known for its high toxicity and its potential to cause respiratory irritation and burns upon contact with the skin. It is handled and stored with extreme caution due to its hazardous properties.

Upstream product

• 209861-00-7 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybutan-1-en-1-yl)-hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate 
• 39746-01-5 (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one 
• 51638-91-6 (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 2065-23-8 methyl 2-phenoxyacetate 
• 31752-99-5 (-)-Corey lactone 5-(4-phenylbenzoate) 
• 38754-71-1 (3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate 
• 542-92-7 cyclopenta-1,3-diene 
• 5623-52-9 rac-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxole 
• 1487-05-4 rac-(trans)-3,3-dimethyltetrahydro-5H-oxireno[2',3':3,4]cyclopenta[1,2-d][1,3]dioxole 
• 29782-85-2 rac-(trans)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-ol 
• 81190-06-9 [(3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-5-(phenylmethoxy)-2H-cyclopenta[b]furan-2-one] 
• 163074-98-4 [(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde] 

Downstream Products

• 209861-02-9 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol 
• 209860-87-7 tafluprost 
• 209860-88-8 AFP-172 

Relevant articles and documents

Method for large-scale preparation of tafluprost

The invention discloses a method for industrially preparing tafluprost. The method comprises the following steps: taking Corey lactone as an initial raw material, oxidizing, condensing, fluorinating,deprotecting, reducing, re-condensing, esterifying and r

He fluorine front row element intermediate preparation method (by machine translation)

The invention discloses he fluorine front row element intermediate, i.e. formula 5 compound preparation method, including the use of biphenyl formyl protected Corey lactone as raw materials, through oxidation, HWE connected side chain, fluorinated, hydrolysis of deprotection step. Preparation method of this invention has the operability is strong, stable process, intermediates for the preparation of white powder, good stability. (by machine translation)

Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: A novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative

A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.