51638-91-6Relevant articles and documents
Identification and efficient synthetic method for preparation of cyclopentane-1,3-diol impurity in tafluprost drug
Venkatanarayana, Muvvala,Reddy Jaggavarapu, Rama Mohana,Venkata Reddy,Sharathbabu
, p. 210 - 214 (2021/01/06)
In present work, the isolation, synthesis and characterization of the identified triol impurity present in tafluprost is described. This investigation helps to avoid formation of impurity by control the reaction and its leads to improving high yields of t
AMINE SALTS OF PROSTAGLANDIN ANALOGS
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Page/Page column 7-8, (2013/08/28)
The present application relates to amine salts of prostaglandin analogs and their uses for the preparation of substantially pure prostaglandin analogs. Specific embodiments relate to amine salts of tafluprost and their uses for the preparation of substant
Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: A novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative
Matsumura, Yasushi,Mori, Nobuaki,Nakano, Takashi,Sasakura, Hideshi,Matsugi, Takeshi,Hara, Hideaki,Morizawa, Yoshitomi
, p. 1527 - 1529 (2007/10/03)
A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.