209901-86-0Relevant articles and documents
A Series of Zn(II) Terpyridine-Based Nitrate Complexes as Two-Photon Fluorescent Probe for Identifying Apoptotic and Living Cells via Subcellular Immigration
Liu, Dandan,Zhang, Mingzhu,Du, Wei,Hu, Lei,Li, Fei,Tian, Xiaohe,Wang, Aidong,Zhang, Qiong,Zhang, Zhongping,Wu, Jieying,Tian, Yupeng
, p. 7676 - 7683 (2018)
Two-photon active probe to label apoptotic cells plays a significant role in biological systems. However, discrimination of live/apoptotic cells at subcellular level under microscopy remains unachieved. Here, three novel Zn(II) terpyridine-based nitrate c
White-light-emitting lanthanide and lanthanide-iridium doped supramolecular gels: modular luminescence and stimuli-responsive behaviour
Singha Mahapatra, Tufan,Singh, Harwinder,Maity, Arunava,Dey, Ananta,Pramanik, Sumit Kumar,Suresh, Eringathodi,Das, Amitava
, p. 9756 - 9766 (2018)
Light-emitting materials are of significant interest owing to their potential applications in electroluminescent devices/displays and sensors. Herein, light-emitting metallogel systems are developed using self-assembled Ln(iii)-complexes (Ln(iii) = Eu(iii
Synthesis, characterization and anticancer mechanism studies of fluorinated cyclometalated ruthenium(ii) complexes
Wen, Ya,Ouyang, Cheng,Li, Quanwen,Rees, Thomas W.,Qiu, Kangqiang,Ji, Liangnian,Chao, Hui
supporting information, p. 7044 - 7052 (2020/06/04)
The drug-resistance of cancer cells has become a major obstacle to the development of clinical drugs for chemotherapy. In order to overcome cisplatin-resistance, seven cyclometalated ruthenium(ii) complexes were synthesized with a varying degree of fluorine substitution, for use as anticancer agents. A cytotoxicity assay testified that the complexes possessed a more cytotoxic effect than cisplatin towards the cisplatin-resistant cell line A549R. The number of fluorine atoms regulated the lipophilicity of the complexes, but the relationship was not linear.Ru1containing one fluorine atom had the highest lipophilicity and the best therapeutic effect. The complexes enter cells through an energy-dependent pathway and then localize in the nuclei and mitochondria. The complexes induced nuclear dysfunction by the inhibition of DNA replication as well as mitochondrial dysfunction by the loss of membrane potential. The damage to these vital organelles leads to cell apoptosisviathe caspase 3/7 pathway. Our results indicated that the modulation of the number of fluorine atoms in therapeutic agents can have a profound effect andRu1is a complex with a high potential as a drug for the treatment of cisplatin-resistant cancer.
Ruthenium(II) Complexes of 4′-(Aryl)-2,2′:6′,2′′-terpyridyl Ligands as Simple Catalysts for the Transfer Hydrogenation of Ketones
Maity, Apurba,Sil, Amit,Patra, Sanjib K.
supporting information, p. 4063 - 4073 (2018/09/11)
A series of cationic [Ru(L)(PPh3)2Cl]+ (1–3) and neutral [Ru(L)(PPh3)Cl2] (4–6) RuII complexes were synthesized by reacting [RuCl2(PPh3)2] with 4′-(aryl)-2,2′:6′,2′′-terpyridyl-based ligands (L1–L3) with various aryl groups (tolyl, phenyl and 4-fluorophenyl). The synthesized RuII complexes were unambiguously characterized by various spectroscopic techniques such as FTIR and multinuclear NMR spectroscopy as well as HRMS. The neutral complexes (4–6) were also structurally characterized by single-crystal X-ray diffraction studies. Photophysical and electrochemical studies of the RuII complexes were performed to elucidate the effects of the 4′-aryl substituents of L1–L3. These RuII complexes show good catalytic activities in the transfer hydrogenation (TH) of ketones with a wide substrates scope in 2-propanol under reflux. An optimization study revealed that the neutral RuII complexes are better catalysts than the cationic RuII complexes for TH reactions. Finally, [Ru(L1)(PPh3)2H]+ (7) with a [RuII–H] functionality was successfully synthesized and isolated and is proposed as the catalytically active species. A control experiment with the [RuII–H] complex in the absence of base was performed to establish the mechanism for the catalytic TH of ketones.
