2103-92-6

Basic information

• Product Name: 4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL
• Synonyms: 4-p-Tolylthiazole-2-thiol;4-(4-methylphenyl)-3H-1,3-thiazole-2-thione;4-(4-methylphenyl)-3H-thiazole-2-thione
• CAS NO: 2103-92-6
• Molecular Formula: C₁₀H₉NS₂
• Molecular Weight: 207.32
• Mol File: 2103-92-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 190-191 °C(Solv: acetone (67-64-1); water (7732-18-5))
• Boiling Point: 347°Cat760mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 5.53E-05mmHg at 25°C
• Refractive Index: 1.715
• PKA: 7.96±0.40(Predicted)
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL(2103-92-6)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL(2103-92-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 2103-92-6(Hazardous Substances Data)

Usage

Description

4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL is a chemical compound with the molecular formula C10H8S2. It belongs to the thiazole class of compounds and contains a thiazole ring with a methylphenyl group attached at the 4-position. Thiazoles have diverse biological activities and are used in the synthesis of various pharmaceuticals and agrochemicals. The 2-thiol group in this compound also imparts reactivity and can participate in various chemical reactions. This chemical may have potential applications in fields such as drug discovery, material science, and organic synthesis.

Uses

Used in Pharmaceutical Industry:
4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL is used as a building block for the synthesis of pharmaceuticals due to its diverse biological activities and potential to be incorporated into drug molecules.
Used in Agrochemical Industry:
4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL is used as a precursor in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural products.
Used in Material Science:
4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL is used as a component in the development of new materials, taking advantage of its reactivity and potential to form various chemical structures.
Used in Organic Synthesis:
4-(4-METHYLPHENYL)-1,3-THIAZOLE-2-THIOL is used as a reagent in organic synthesis, enabling the creation of a wide range of chemical compounds for research and industrial applications.

InChI:InChI=1/C10H9NS2/c1-7-2-4-8(5-3-7)9-6-13-10(12)11-9/h2-6H,1H3,(H,11,12)

Upstream product

• 6097-27-4 2-thiocyanato-1-(4-tolyl)ethanone 
• 125172-89-6 [(4-methylphenyl)ethynyl](phenyl)iodonium tosylate 
• 513-74-6 ammonium dithiocarbamate 
• 98475-04-8 1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 122-00-9 para-methylacetophenone 
• 619-41-0 4-(bromoacetyl)toluene 
• 5337-93-9 4'-methylpropiophenone 
• 75-15-0 carbon disulfide 
• 69143-26-6 2-methanesulfonyl-1-p-tolyl-ethylideneamine 
• 104-85-8 para-methylbenzonitrile 
• 53983-40-7 triethylammonium dithiocarbamate 

Downstream Products

• 69390-11-0 2-butylsulfanyl-4-p-tolyl-thiazole 
• 2103-89-1 2-methylmercapto-4-(4'-methylphenyl)thiazole 
• 130459-59-5 (4-p-Tolyl-thiazol-2-ylsulfanyl)-acetonitrile 
• 112779-70-1 ethyl <4-(4'-methylphenyl)thiazol-2-ylthio>acetate 
• 112779-59-6 3-<4'-(4''-methylphenyl)thiazol-2'-ylthio>-8-methoxy-2H-1-benzopyran-2-one 
• 112779-58-5 3-<4'-(4''-methylphenyl)thiazol-2'-ylthio>-2H-1-benzopyran-2-one 
• 112779-67-6 <4-(4'-methylphenyl)thiazol-2-ylthio>acetic acid hydrazide 
• 112779-64-3 (4-p-Tolyl-thiazol-2-ylsulfanyl)-acetic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 112779-65-4 (4-p-Tolyl-thiazol-2-ylsulfanyl)-acetic acid [1-(2-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 116626-06-3 5-(4-p-Tolyl-thiazol-2-ylsulfanylmethyl)-[1,3,4]oxadiazole-2-thiol 
• 116643-29-9 2-Methylsulfanyl-5-(4-p-tolyl-thiazol-2-ylsulfanylmethyl)-[1,3,4]oxadiazole 
• 130459-67-5 8-Methoxy-3-(4-p-tolyl-thiazol-2-ylsulfanyl)-chromen-2-ylideneamine 
• 130459-63-1 3-(4-p-Tolyl-thiazol-2-ylsulfanyl)-chromen-2-ylideneamine 
• 500193-63-5 2-(3-propyl-1-phenyl-4,5-dihydro-5-oxopyrazol-4-thio)-4-(4-methylphenyl)thiazole 

Relevant articles and documents

Synthesis of novel azabicyclo derivatives containing a thiazole moiety and their biological activity against pine-wood nematodes

To explore a new skeleton with nematicidal activity, a series of novel azabicyclo derivatives containing a thiazole moiety were designed, synthesized and evaluated for their nematicidal activities. The bioassay results against pine-wood nematodes (Bursaphelenchus xylophilus) showed that most of the title compounds displayed nematicidal activity at a concentration of 40 mg/L. Especially, the title compounds2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)oxy)-4-(4-chlorophenyl)thiazole (7e), 2-((8-methyl-8-azabicyclo[3.2.1]octan-3-yl)thio)-4-phenylthiazole (10a) and 2-((8-methyl-8-azabicyclo [3.2.1]octan-3-yl)thio)-4-(4-chlorophenyl)thiazole (10e) exhibited more than 90% mortality against Bursaphelenchus xylophilus.

An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3: H)-thiones employing flow processing

A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.

Synthesis new and novel aryl thiazole derivatives compounds

Six new compounds of Thiazoles family was synthesis from condensation reaction of some compounds from pyrazolines. NMR, IR and elemental analysis was used for identification of these compounds. Position of aliphatic and aromatic hydrogens in pyrazolone and thiazole cycles had established proceeding of identification. Most of obtained compounds like aciform crystals, their color is white and yellow. Reaction time and yield of these compounds had shown better results as compared with other thiazole derivations.