210753-64-3

Basic information

• Product Name: 2-Fluoro-3-hydroxy-2-(hydroxy-phenyl-methyl)-3-phenyl-propionic acid ethyl ester
• Synonyms: 2-Fluoro-3-hydroxy-2-(hydroxy-phenyl-methyl)-3-phenyl-propionic acid ethyl ester
• CAS NO: 210753-64-3
• Molecular Weight: 318.345
• Mol File: 210753-64-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Fluoro-3-hydroxy-2-(hydroxy-phenyl-methyl)-3-phenyl-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-hydroxy-2-(hydroxy-phenyl-methyl)-3-phenyl-propionic acid ethyl ester(210753-64-3)
• EPA Substance Registry System: 2-Fluoro-3-hydroxy-2-(hydroxy-phenyl-methyl)-3-phenyl-propionic acid ethyl ester(210753-64-3)

Safety Data

• Hazardous Substances Data: 210753-64-3(Hazardous Substances Data)

Upstream product

• 565-53-7 ethyl dibromofluoroacetate 
• 100-52-7 benzaldehyde 

Downstream Products

• 20397-59-5 ethyl (Z)-2-fluoro-3-phenylacrylate 

Relevant articles and documents

Zinc-Diethylaluminium Chloride Induced Coupling Reaction of Dibromofluoroacetate with Carbonyl Compounds. New Efficient and Selective Synthesis of α-Bromo-α-fluoro-β-hydroxy and α-Fluoro-β,β'-dihydroxy Esters

Treatment of ethyl dibromofluoroacetate with aldehydes or ketone in the presence of zinc and diethylaluminium chloride at -20 deg C gave rise to the corresponding α-bromo-α-fluoro-β-hydroxy alkanoic acid ethyl esters in good yields, while the use of two equivalents each of aldehyde, zinc, and diethylaluminium chloride in the reaction resulted in a double coupling reaction affording the 1:2 adducts, α-fluoro-β,β'-dihydroxy esters in high yields.