21118-89-8

Basic information

• Product Name: Propanedioic acid, [(4-methoxyphenyl)methyl]methyl-, dimethyl ester
• CAS NO: 21118-89-8
• Molecular Formula: C14H18O5
• Molecular Weight: 266.294
• Mol File: 21118-89-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(4-methoxyphenyl)methyl]methyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(4-methoxyphenyl)methyl]methyl-, dimethyl ester(21118-89-8)
• EPA Substance Registry System: Propanedioic acid, [(4-methoxyphenyl)methyl]methyl-, dimethyl ester(21118-89-8)

Safety Data

• Hazardous Substances Data: 21118-89-8(Hazardous Substances Data)

Upstream product

• 609-02-9 methyl-malonic acid dimethylester 
• 2746-25-0 p-Methoxybenzyl bromide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 129152-02-9 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-3-methyl-4-oxo-1,5-benzothiazepine-3-carboxylic acid, methyl ester 
• 129152-02-9 (2R,3S)-2-(4-Methoxy-phenyl)-3-methyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepine-3-carboxylic acid methyl ester 
• 129152-05-2 cis-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one hydrochloride 
• 129152-01-8 2-<<(2-aminophenyl)thio>(4-methoxyphenyl)methyl>-2-methylpropanedioic acid, dimethyl ester 
• 129152-03-0 1,2,3,4-tetrahydro-2-(4-methoxyphenyl)-3-methyl-4-oxo-1,5-benzothiazepine-3-carboxylic acid 
• 129152-04-1 cis-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-1,5-benzothiazepin-4(5H)-one 
• 65555-88-6 α-methyl-β-p-methoxyphenyl-alanine 
• 672-87-7 L-methyltyrosine 
• 21186-54-9 (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester 
• 129152-00-7 2--2-methylpropanedioic acid, dimethyl ester 

Relevant articles and documents

Palladium catalyzed direct benzylation/allylation of malonates with alcohols-: In situ C-O bond activation

High step- and atom-economy are the endlessly pursued in organic and pharmaceutical syntheses. Herein, a new method for directly coupling benzyl/allyl alcohols with malonates via a palladium catalyzed Tsuji-Trost type reaction was developed. The reaction was carried out in an organic carbonate solvent which would activate alcohols in situ, replacing the traditional pre-synthesized carbonates. The new process demonstrated high efficiency, high selectivity and high generality. A wide variety of mono-substituted and bis-substituted malonates were selectively produced under different conditions, and this method represents a more step- and atom-economical and environmentally benign synthetic protocol.

ENZYME CATALYSED HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, SYNTHESIS OF OPTICALLY PURE (S)-α-METHYLPHENYLALANINE, (S)-α-METHYLTYROSINE AND (S)-α-METHYL-3,4-DIHYDROXYPHENYLALANINE

Pig liver esterase and α-chymotrypsin catalysed hydrolysis of the meso-diesters 1, 2 and 3 gave the corresponding monoesters which then could be transformed into enantiomerically pure (S)-α-methylphenylalanine, (S)-α-methyltyrosine and (S)-α-methyl-3,4-dihydroxyphenylalanine.