21186-54-9

Basic information

• Product Name: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester
• Synonyms: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester
• CAS NO: 21186-54-9
• Molecular Weight: 252.267
• Mol File: 21186-54-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester(21186-54-9)
• EPA Substance Registry System: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid monomethyl ester(21186-54-9)

Safety Data

• Hazardous Substances Data: 21186-54-9(Hazardous Substances Data)

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 21118-89-8 2-<(4-methoxyphenyl)methyl>-2-methylpropanedioic acid, dimethyl ester 

Downstream Products

• 65555-88-6 α-methyl-β-p-methoxyphenyl-alanine 
• 672-87-7 L-methyltyrosine 

Relevant articles and documents

ENZYME CATALYSED HYDROLYSIS OF DIALKYLATED PROPANEDIOIC ACID DIESTERS, SYNTHESIS OF OPTICALLY PURE (S)-α-METHYLPHENYLALANINE, (S)-α-METHYLTYROSINE AND (S)-α-METHYL-3,4-DIHYDROXYPHENYLALANINE

Pig liver esterase and α-chymotrypsin catalysed hydrolysis of the meso-diesters 1, 2 and 3 gave the corresponding monoesters which then could be transformed into enantiomerically pure (S)-α-methylphenylalanine, (S)-α-methyltyrosine and (S)-α-methyl-3,4-dihydroxyphenylalanine.