21120-36-5

Basic information

• Product Name: 2'-FLUOROPROPIOPHENONE
• Synonyms: (R,S)-2-Fluoro-1-phenyl-propan-1-one;R,S-2-Fluoro-1-phenyl-propan-1-one;1-(2-FLUOROPHENYL)PROPAN-1-ONE;ETHYL 2-FLUOROPHENYL KETONE;1-Propanone, 2-fluoro-1-phenyl- (9CI);2-Fluoro-1-phenyl-1-propanone;α-Fluoropropiophenone;Einecs 244-220-7
• CAS NO: 21120-36-5
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• EINECS: 244-220-7
• Product Categories: ACETYLHALIDE
• Mol File: 21120-36-5.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 95-99 °C19 mm Hg(lit.)
• Flash Point: 175 °F
• Appearance: /
• Density: 1.102 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5043(lit.)
• CAS DataBase Reference: 2'-FLUOROPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUOROPROPIOPHENONE(21120-36-5)
• EPA Substance Registry System: 2'-FLUOROPROPIOPHENONE(21120-36-5)

Safety Data

• Statements: R36/38:
• Safety Statements: S 22;R36:
• WGK Germany: 3
• Hazardous Substances Data: 21120-36-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 21, p. 2257, 1980 DOI: 10.1016/0040-4039(80)80018-9

Upstream product

• 349-43-9 ethyl 2-fluoropropionate 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 
• 88208-13-3 2-fluoro-1-phenyl-1-propanol 
• 673-32-5 1-Phenylprop-1-yne 
• 67-56-1 methanol 
• 6202-57-9 2-Chlor-3-methyl-2-phenyloxiran 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 
• 5650-40-8 2-hydroxypropiophenone 
• 39623-95-5 1-phenylprop-1-enyl acetate 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 6202-57-9 chloro-2-phenyl-2-methyl-3-oxiranne (Z) 
• 134414-80-5 N-Fluoro-o-benzenedisulfonimide 
• 93-55-0 1-phenyl-propan-1-one 
• 16205-14-4 2-Methyl-3-phenyl-2H-azirine 

Downstream Products

• 63801-22-9 2-phenylpentan-3-one 
• 63017-06-1 2-bromo-2-fluoropropiophenone 
• 88208-13-3 2-fluoro-1-phenyl-1-propanol 
• 63017-20-9 2-chloro-2-fluoro-1-phenylpropane-1-one 
• 81182-34-5 [2-Fluoro-1-phenyl-prop-(E)-ylidene]-isopropyl-amine 
• 73611-94-6 2-fluoro-1,1-dimethoxy-1-phenylpropane 
• 765271-39-4 methyl 2-fluoro-2-methyl-3-oxo-3-phenylpropionate 
• 121059-34-5 [5-Chloro-2-fluoro-2-methyl-1-phenyl-pent-(E)-ylidene]-isopropyl-amine 
• 7624-24-0 1-methoxy-1-phenyl-acetone 
• 73611-95-7 2-fluoro-1-methoxy-1-phenylpropene 
• 73611-96-8 2-fluoro-1-methoxy-1-phenylpropene 
• 57711-28-1 1,1-dimethoxy-1-phenylpropan-2-one 
• 76650-18-5 1-Chloro-1-ethoxy-1-phenyl-propan-2-one 
• 76650-19-6 1-Ethoxy-1-isopropoxy-1-phenyl-propan-2-one 

Relevant articles and documents

Rh-Catalyzed arylation of fluorinated ketones with arylboronic acids

The Rh-catalyzed arylation of fluorinated ketones with boronic acids is reported. This efficient process allows access to fluorinated alcohols in high yields under mild conditions. Competition experiments suggest that difluoromethyl ketones are more reactive than trifluoromethyl ketones in this process, despite their decreased electronic activation, an effect we postulate to be steric in origin.

Formal Fluorinative Ring Opening of 2-Benzoylpyrrolidines Utilizing [1,2]-Phospha-Brook Rearrangement for Synthesis of 2-Aryl-3-fluoropiperidines

A ring expansion of 2-benzoylpyrrolidines, which involves the formal fluorinative ring opening utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis and a subsequent intramolecular reductive amination, was developed. The operationally simple three-step protocol provides an efficient access to 2-aryl-3-fluoropiperidines. The methodology was further applied to the syntheses of azepanes and tetrahydroquinolines.

Method for synthesizing alpha-fluorinated ketone through hydrazone aliphatic chain monoketone

The invention belongs to the technical field of organic synthesis, and provides a method for synthesizing alpha-ketone fluoride through hydrazone aliphatic chain monoketone, which comprises the following steps of: reacting aliphatic chain monoketone with hydrazine hydrate to obtain hydrazone, and reacting hydrazone with a compound represented by formula 2 under a heating condition to complete hydrazone defluorination. The fluorinated product is widely applied to medicines, the reaction conditions are mild, and the process is simple.