212688-02-3Relevant articles and documents
Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled Bischler-Napieralski reaction and an electrochemically generated diaryl ether
Kawabata, Yuki,Naito, Yu,Saitoh, Tsuyoshi,Kawa, Kohei,Fuchigami, Toshio,Nishiyama, Shigeru
, p. 99 - 104 (2014/01/06)
An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O
Total synthesis of antibacterial dibromotyrosine derived alkaloid purpuramine-K#
Reddy, S. Malla,Srinivasulu,Venkateswarlu
, p. 2757 - 2762 (2007/10/03)
The first total synthesis of a dibromotyrosine derived alkaloid purpuramine K 1 reported for possible anti-bacterial activity against gram-positive bacteria viz: Staphylococcus aureus, Bacillus subtilis, Bacillus sphaericus and gram-negative bacteria like Chromobacterium violaceum, Klebsiella aerogenes, and Pseudomonas aeruginosa has been achieved. The synthesis involves preparation of methyl-3-bromopropyl carbamate 6, and Boc protected 2-[3,5-dibromo, 4-hydroxy phenyl] ethyl amine 13 which is followed by coupling of these two structural fragments to give corresponding ether 14. After deprotection of Boc group in compound 14, it is reacted with 4-hydroxyphenyl pyruvic acid oxime derivative 17 using EDCI/HOBT to give compound 18, which is further transformed to purpuramine K.
Thyroid receptor ligands and method
-
, (2008/06/13)
Novel thyroid receptor ligands are provided which have the general formula (I) where R1is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2and R3are the same or different and are hydrogen, halogen, alkyl of 1 to