212688-03-4

Basic information

• Product Name: 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester
• Synonyms: 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester
• CAS NO: 212688-03-4
• Molecular Weight: 337.996
• Mol File: 212688-03-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester(212688-03-4)
• EPA Substance Registry System: 3,5-dibromo-4-methoxy-phenyl acetic acid methyl ester(212688-03-4)

Safety Data

• Hazardous Substances Data: 212688-03-4(Hazardous Substances Data)

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 212688-02-3 3,5-dibromo-4-hydroxyphenylacetic acid methyl ester 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1007893-78-8 (3,5-dibromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1007893-79-9 (6-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 1007893-80-2 (7-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 212688-04-5 4-(3,5-Dibromo-4-methoxy-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-butyronitrile 

Relevant articles and documents

First total synthesis of the alkaloid polycitrin B

Starting from 3,5-dibromo-4-methoxy-phenylacetic acid methyl ester 2, a first total synthesis of the marine alkaloid polycitrin B is reported, based on the Pd catalyzed coupling reaction of the triflate 4 with the (4- methoxymethoxy-phenyl)tributylstannan

Total synthesis of pulmonarin B and design of brominated phenylacetic acid/tacrine hybrids: Marine pharmacophore inspired discovery of new CHE and Aβ aggregation inhibitors

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory activity, while the hybrid 12j proved to be the most potent dual inhibitor among the designed derivatives, being almost as active as tacrine. Molecular modeling studies together with kinetic analysis suggested that 12j interacted with both the catalytic active site and peripheral anionic site of AChE. Compounds 1 and 12j could also inhibit self-induced and AChE-induced Aβ aggregation. In addition, the cell-based assay against the human hepatoma cell line (HepG2) revealed that 1 and 12j did not show significant hepatotoxicity compared with tacrine and donepezil. Taken together, the present study confirmed that compound 1 was a potential anti-Alzheimer’s disease (AD) hit, and 12j could be highlighted as a multifunctional lead compound for anti-AD drug development.

Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin using the cyano ylide coupling methodology

Syntheses of the marine metabolites verongamine, hemibastadin-2, and aerothionin have been accomplished by a methodology involving the conversion of a carboxylic acid to an acyl cyano phosphorane which may be oxidized to an α,β-diketo nitrile. This strong