21278-77-3

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• Synonyms: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBALDEHYDE;2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• CAS NO: 21278-77-3
• Molecular Formula: C₁₀H₆ClNOS
• Molecular Weight: 223.68
• Mol File: 21278-77-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 377.571 °C at 760 mmHg
• Flash Point: 182.149 °C
• Appearance: /
• Density: 1.388 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: 2-8°C
• PKA: -0.30±0.10(Predicted)
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(21278-77-3)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(21278-77-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 21278-77-3(Hazardous Substances Data)

Usage

General Description

2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde is a chemical compound with the molecular formula C10H6ClNO. It is a pale yellow to light brown powder with a molecular weight of 197.61 g/mol. 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in the production of various organic compounds and has potential applications in research and development. Its chemical properties and structure make it suitable for use in a wide range of chemical reactions and processes.

InChI:InChI=1/C10H6ClNOS/c11-8-3-1-7(2-4-8)10-12-9(5-13)6-14-10/h1-6H

Upstream product

• 40361-62-4 4-chloromethyl-2-(4-chloro-phenyl)-4,5-dihydro-thiazol-4-ol 
• 2521-24-6 4-chlorothiobenzamide 
• 623-03-0 4-Cyanochlorobenzene 
• 61786-00-3 ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate 
• 17969-22-1 4-chloromethyl-2-(4-chloro-phenyl)-thiazole 
• 20287-70-1 ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate 

Downstream Products

• 36093-99-9 [2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 108735-90-6 2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde oxime 
• 17969-21-0 2-(4-chlorophenyl)thiazole-4-carbonitrile 
• 174006-80-5 2-(4-chlorophenyl)thiazole-4-carbothioamide 
• 52041-83-5 [5-bromo-2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 52041-93-7 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carbaldehyde 
• 52041-97-1 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carboxylic acid 
• 1187020-64-9 4-[2-(4-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-diacethyl-1,4-dihydropyridine 
• 1187020-68-3 4-[2-(4-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-dibenzoyl-1,4-dihydropyridine 
• 1244030-74-7 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 
• 1585214-70-5 rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-74-9 (R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-86-3 (S)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-82-9 (R)-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate 

Relevant articles and documents

Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents

To search for potent antimycobacterial lead compounds, a new series of 3-substituted phenyl-2-(2-(substituted phenyl)thiazol-4-yl) thiazolidin-4-one (5a-t) derivatives have been synthesized by the condensation of 2-substituted phenyl thiazole-4-carbaldehy

Heterocycles 44. Synthesis, characterization and anticancer activity of new thiazole ortho-hydroxychalcones

A novel series of substituted thiazole ortho-hydroxychalcones was synthesized to be physico-chemically characterized and evaluated for the anticancer activity. The chalcones were synthesized with 28–68% yields, via Claisen–Schmidt condensation in an ethanolic solution. All the synthesized compounds were purified and characterized by MS, 1H NMR, 13C NMR, IR, and melting points. The cytotoxicity of thiazole ortho-hydroxychalcones 3a–3o as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Compounds 3a, 3b, 3c, 3j, as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values below 75 μM. The best samples showed IC50 values below 10 μM against 5/9 cancer cell lines for 3a, 3h, and 3o, against 7/9 cancer cell lines for 3c and 3f, and against 8/9 cancer cell lines for 3j. Hypersensitivity of all resistant cells towards 3b, 3g, 3j, 3m, and 3o was also obtained, suggesting that these compounds are appropriate molecules that could be used to combat drug resistance of cancer cells.

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.