213211-69-9

Basic information

• Product Name: 2-ETHOXYPHENYLBORONIC ACID
• Synonyms: RARECHEM AH PB 0149;2-ETHOXYPHENYLBORONIC ACID;2-ETHOXYBENZENEBORONIC ACID;AKOS BRN-0068;BORONIC ACID, (2-ETHOXYPHENYL)-;2-Ethoxyphenylboronic Acid (contains varying amounts of Anhydride);2-Ethoxyphenylboronic acid,98%;Ethoxyphenylboronic acid
• CAS NO: 213211-69-9
• Molecular Formula: C₈H₁₁BO₃
• Molecular Weight: 165.98
• Product Categories: blocks;BoronicAcids;Boronic Acid;B (Classes of Boron Compounds);Boronic Acids;Aryl;Boronic Acids;Boronic Acids and Derivatives;Aryl Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Monosubstituted Aryl Boronic Acids;Organometallic Reagents;Boronate Ester;Potassium Trifluoroborate
• Mol File: 213211-69-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 97-102 °C(lit.)
• Boiling Point: 328.8 °C at 760 mmHg
• Flash Point: 152.7 °C
• Appearance: White to off-white/Crystalline Powder or Crystals
• Density: 1.13 g/cm³
• Vapor Pressure: 7.43E-05mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Refrigerator (+4°C)
• Solubility: soluble in Methanol
• PKA: 8.57±0.58(Predicted)
• CAS DataBase Reference: 2-ETHOXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXYPHENYLBORONIC ACID(213211-69-9)
• EPA Substance Registry System: 2-ETHOXYPHENYLBORONIC ACID(213211-69-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 213211-69-9(Hazardous Substances Data)

Usage

Description

2-Ethoxyphenylboronic acid is an organic compound that exists as white to off-white crystals or a crystalline powder. It is a boronic acid derivative with a chemical structure featuring an ethoxy group attached to a phenyl ring, which is further connected to a boronic acid group. This unique structure endows it with versatile reactivity and utility in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
2-Ethoxyphenylboronic acid is used as a reactant for the synthesis of various pharmaceutical compounds, including pyridines and pyrimidines, which are important building blocks in the development of new drugs. Its involvement in Suzuki-Miyaura cross-coupling reactions allows for the formation of complex molecular structures with potential therapeutic applications.
Used in Chemical Research:
2-Ethoxyphenylboronic acid is used as a reactant in various chemical research applications, such as the synthesis of bromo-N-methylpyrrole and diarylbenzophenones. These compounds have potential uses in the development of new materials and chemicals with specific properties.
Used in Catalyst Development:
2-Ethoxyphenylboronic acid is used as a reactant in the study of the effect of biaryl phosphine ligand structure on C-N and C-C bond formation. This research is crucial for the development of more efficient and selective catalysts for various chemical reactions.
Used in Material Science:
2-Ethoxyphenylboronic acid is used as a reactant in oxidative coupling via C-H arylation, a process that can lead to the formation of new materials with unique properties. This application is particularly relevant in the field of material science, where the development of novel materials with specific characteristics is of great interest.

InChI:InChI=1/C8H11BO3/c1-2-12-8-6-4-3-5-7(8)9(10)11/h3-6,10-11H,2H2,1H3

Upstream product

• 92838-43-2 Hg(C₆H₄-2-OC₂H₅)2 
• 688-74-4 boric acid tributyl ester 
• 41842-29-9 2-ethoxyphenylmagnesium bromide 
• 7732-18-5 water 

Downstream Products

• 851194-11-1 4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 1073485-22-9 4-chloro-6-(2-ethoxy-phenyl)-pyrimidine 
• 1000851-46-6 2-[3-(2-ethoxy-phenyl)-thiophen-2-yl]-pyridine 
• 358741-44-3 2-(2-ethoxyphenyl)pyridine 
• 883443-99-0 (2R,3S,5R)-5-[(1S,2S)-1-Hydroxy-2-acetylamino-3-(3-(2-ethoxyphenyl)-5-fluorophenyl)-propyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester 
• 881311-32-6 ethyl N-[2-(2'-ethoxybiphenyl-4-yl)quinolin-4-yl]-beta-alaninate 
• 881314-46-1 methyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoroquinolin-4-yl]methyl}glycinate 
• 881314-39-2 methyl {[2-(2'-ethoxybiphenyl-4-yl)-6-fluoroquinolin-4-yl]methoxy}acetate 
• 881313-78-6 2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-ol 
• 881310-92-5 ethyl N-[2-(2'-ethoxybiphenyl-4-yl)quinazolin-4-yl]-beta-alaninate 
• 881312-75-0 ethyl N-[2-(2'-ethoxybiphenyl-4-yl)-6-fluoroquinolin-4-yl]-beta-alaninate 
• 881312-69-2 ethyl 1-[2-(2'-ethoxybiphenyl-4-yl)-7-methoxyquinolin-4-yl]piperidine-4-carboxylate 
• 641611-84-9 2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid 
• 473611-05-1 2-Chloro-2'-ethoxy-5-methoxy-[1,1'-biphenyl]-4-carboxylic acid