214209-95-7

Basic information

• Product Name: 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride
• Synonyms: 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride
• CAS NO: 214209-95-7
• Molecular Weight: 250.566
• Mol File: 214209-95-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride(214209-95-7)
• EPA Substance Registry System: 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride(214209-95-7)

Safety Data

• Hazardous Substances Data: 214209-95-7(Hazardous Substances Data)

Upstream product

• 4654-39-1 4-bromophenethanol 
• 114369-15-2 2-(4-bromophenyl)ethyl methanesulfonate 
• 74-89-5 methylamine 
• 7713-76-0 2-(4-bromophenyl)-N-methylethanamide 

Relevant articles and documents

Convenient Continuous Flow Synthesis of N-Methyl Secondary Amines from Alkyl Mesylates and Epoxides

The first continuous flow process was developed to synthesize N-methyl secondary amines from alkyl mesylates and epoxides via a nucleophilic substitution using aqueous methylamine. A variety of N-methyl secondary amines were produced in good to excellent yields, including a number of bioactive compounds or their precursors. Up to 10.6 g (88% yield) of an N-methyl secondary amine was produced in 140 min process time. The amination procedure included an in-line workup, and the starting mesylate material was also produced in continuous flow from the corresponding alcohol. Finally, an in-line process combining the mesylate synthesis and nucleophilic substitution was developed.