7713-76-0

Basic information

• Product Name: 2-(4-bromophenyl)-N-methylacetamide
• Synonyms: 2-(4-bromophenyl)-N-methylacetamide;2-(4-bromophenyl)-N-methylacetamide(SALTDATA: FREE);2-(4-bromophenyl)-N-methyl-ethanamide;AG-690/15442359;BAS 02256157;ZINC00373125
• CAS NO: 7713-76-0
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.1
• Product Categories: alkyl bromide
• Mol File: 7713-76-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.9°C at 760 mmHg
• Flash Point: 190.8°C
• Appearance: /
• Density: 1.417g/cm³
• Vapor Pressure: 2.39E-06mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-bromophenyl)-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-N-methylacetamide(7713-76-0)
• EPA Substance Registry System: 2-(4-bromophenyl)-N-methylacetamide(7713-76-0)

Safety Data

• Hazardous Substances Data: 7713-76-0(Hazardous Substances Data)

Usage

General Description

2-(4-bromophenyl)-N-methylacetamide is a chemical compound with the molecular formula C10H11BrNO, which consists of a 4-bromophenyl group and a N-methylacetamide group. It is commonly used as a building block in the synthesis of pharmaceutical compounds and organic materials. The compound is a white to off-white solid and is soluble in organic solvents. It is also known for its potential biological activities and has been studied for its pharmacological properties. Additionally, it is important to handle this chemical with care as it may pose health hazards if swallowed, inhaled, or exposed to skin and eyes.

InChI:InChI=1/C9H10BrNO/c1-11-9(12)6-7-2-4-8(10)5-3-7/h2-5H,6H2,1H3,(H,11,12)

Upstream product

• 7713-75-9 <4-Brom-phenyl>-malonsaeure-N-methylamid 
• 7713-59-9 4-(4-bromo-phenyl)-2-methyl-2H-isoxazol-5-one 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 74-89-5 methylamine 
• 109-72-8 n-butyllithium 
• 149652-50-6 2-(4-bromophenyl)-N-methoxy-N-methylacetamide 

Downstream Products

• 865111-81-5 1,1-dimethylethyl 7-{4-[2-(methylamino)-2-oxoethyl]phenyl}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 214209-95-7 2-(4-bromophenyl)-N-methylethan-1-amine hydrochloride 
• 877265-10-6 7-bromo-2-methyl-1,4-dihydro-2H-isoquinolin-3-one 
• 1256359-34-8 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N-methylethanamide 
• 725683-06-7 2-(4-bromophenyl)-N-methylethan-1-amine 

Relevant articles and documents

One-pot sequential 1,2-addition, Pd-catalysed cross-coupling of organolithium reagents with Weinreb amides

An efficient sequential 1,2-addition/cross-coupling of Weinreb amides with two organolithium reagents is reported. This synthetic approach allows access to a wide variety of functionalized ketones in a modular way. The one-pot procedure presented here takes advantage of a kinetically stable tetrahedral Weinreb intermediate during subsequent Pd-catalyzed cross-coupling with the second organolithium reagent leading, within short reaction times and under mild conditions, to the formation of ketones in excellent overall yields.

Process development and pilot-scale synthesis of new cyclization conditions of substituted phenylacetamides to tetrahydroisoquinoline-2-ones using Eaton's reagent

Tetrahydroisoquinoline is a ubiquitous structural framework presented in numerous pharmacologically relevant molecules. Although accessible by the Pictet-Spengler cyclization, conditions commonly used for such cyclizations are often difficult to implement on scale. Herein, we report the development of a scaleable approach utilizing Eaton's reagent for the cyclization of substituted phenylacetamide analogues to tetrahydroisoquinoline-2-one. The development, optimization, and safety hazard evaluations, which outline the benefits and ease of workup of this new process, are discussed.