214282-10-7

Basic information

• Product Name: Benzaldehyde, 4-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methoxy]-
• CAS NO: 214282-10-7
• Molecular Formula: C17H14N2O3
• Molecular Weight: 294.31
• Mol File: 214282-10-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methoxy]-(214282-10-7)
• EPA Substance Registry System: Benzaldehyde, 4-[(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)methoxy]-(214282-10-7)

Safety Data

• Hazardous Substances Data: 214282-10-7(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 40849-13-6 4-hydroxymethyl-2-methyl-1(2H)-phthalazinone 

Downstream Products

• 2295-31-0 thiazoline-2,4-dione 
• 214281-86-4 5-[4-[[2-Methyl-1-oxo-1,2-dihydro-phthalazin-4-yl]methoxy]phenyl methylene]thiazolidin-2,4-dione 

Relevant articles and documents

Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents

We report here the synthesis of a series of 5-[4-[2-[substituted phthalazinones-2(or 4)yl]ethoxy]phenylmethyl]thiazolidine-2,4-diones and 5-[4-[2-[2,3-benzoxazine-4-one-2-yl]ethoxy]phenylmethyl]thiazolidine-2, 4-diones and their plasma glucose and plasma triglyceride lowering activity in db/db mice. In vitro PPARγ transactivation assay was performed in HEK 293T cells. In vitro and in vivo pharmacological studies showed that the phthalazinone analogue has better activity. PHT46 (compound 5a), the best compound in this series, showed better in vitro PPARγ transactivation potential than troglitazone and pioglitazone. In insulin resistant db/db mice, PHT46 showed better plasma glucose and triglyceride lowering activity than the standard drugs. Pharmacokinetic study in Wistar rats showed good systemic exposure of PHT46. Subchronic toxicity study in Wistar rats did not show any treatment-related adverse effect.