214360-63-1

Basic information

• Product Name: 2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: 2-(3-Methyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 214360-63-1
• Molecular Formula: C₁₄H₂₁BO₃
• Molecular Weight: 248.13
• Mol File: 214360-63-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(214360-63-1)
• EPA Substance Registry System: 2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(214360-63-1)

Safety Data

• Hazardous Substances Data: 214360-63-1(Hazardous Substances Data)

Usage

General Description

2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a chemical compound with the molecular formula C16H25BO2. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 2-(4-methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane contains a boron atom, which makes it useful in a variety of cross-coupling reactions, such as Suzuki and Stille couplings. It is a colorless liquid with a high boiling point, making it suitable for use in high-temperature reactions. This chemical is important in the field of medicinal chemistry, as it can be used to create complex molecular structures that may have potential pharmaceutical applications.

Upstream product

• 75581-11-2 1-iodo-4-methoxy-3-methylbenzene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 14804-31-0 2-methyl-4-bromoanisole 
• 73183-34-3 bis(pinacol)diborane 
• 3260-85-3 2-methyl-4-chloroanisole 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 578-58-5 2-methylmethoxybenzene 

Downstream Products

• 1276544-74-1 7-chloro-3-(2-chloro-4-fluorobenzyl)-5-(4-methoxy-3-methylphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one 

Relevant articles and documents

Para -C-H borylation of benzene derivatives by a bulky iridium catalyst

A highly para-selective aromatic C-H borylation has been accomplished. By a new iridium catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C-H borylation of monosubstituted benzenes can be affected with para-selectivity up to 91%. This catalytic system is quite different from the usual iridium catalysts that cannot distinguish meta- and para-C-H bonds of monosubstituted benzene derivatives, resulting in the preferred formation of meta-products. The para-selectivity increases with increasing bulkiness of the substituent on the arene, indicating that the regioselectivity of the present reaction is primarily controlled by steric repulsion between substrate and catalyst. Caramiphen, an anticholinergic drug used in the treatment of Parkinsons disease, was converted into five derivatives via our para-selective borylation. The present [Ir(cod)OH]2/Xyl-MeO-BIPHEP catalyst represents a unique, sterically controlled, para-selective, aromatic C-H borylation system that should find use in streamlined, predictable chemical synthesis and in the rapid discovery and optimization of pharmaceuticals and materials.

Method for preparing aminoarylborane compounds or derivatives thereof

The present invention provides a process for the preparation of aminoarylborane compounds and derivatives thereof comprising a step of arylation by reacting an aryl chloride with an aminoborane compound in the presence of a catalytic system. Typically, th

Non-nucleoside reverse transcriptase inhibitors

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