214470-52-7

Basic information

• Product Name: 6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile
• Synonyms: 4-Hydroxy-6,7-dimethoxychinolin-3-carbonitril; 4-hydroxy-6,7-dimethoxyquinoline-3-carbonitrile; 6,7-Dimethoxy-4-oxo-1,4-dihydrochinolin-3-carbonitril
• CAS NO: 214470-52-7
• Molecular Formula: C₁₂H₁₀N₂O₃
• Molecular Weight: 230.2194
• Mol File: 214470-52-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 387.9°C at 760 mmHg
• Flash Point: 188.4°C
• Density: 1.33g/cm³
• Vapor Pressure: 3.19E-06mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(214470-52-7)
• EPA Substance Registry System: 6,7-dimethoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile(214470-52-7)

Safety Data

• Hazardous Substances Data: 214470-52-7(Hazardous Substances Data)

Upstream product

• 20428-58-4 α-lithioacetonitrile 
• 30199-65-6 2-cyano-3-(3,4-dimethoxyphenylamino)acrylic acid ethyl ester 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 6315-89-5 3,4-dimethoxyaniline 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 50-00-0 formaldehyd 

Downstream Products

• 214470-55-0 4-chloro-6,7-dimethoxyquinoline-3-carbonitrile 
• 957137-98-3 1-(4-chloro-benzyl)-6,7-dimethoxy-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 214484-25-0 4-[(3-bromophenyl)amino]-6,7-dihydroxy-3-quinolinecarbonitrile 
• 214486-09-6 4-(3-aminophenylamino)-6,7-dimethoxy-3-quinolinecarbonitrile 
• 214488-80-9 4-[(3-bromophenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile 

Relevant articles and documents

Copper-Catalyzed Synthesis of Substituted 4-Quinolones using Water as a Benign Reaction Media: Application for the Construction of Oxolinic Acid and BQCA

A copper-catalyzed three-component synthetic method has been developed for the synthesis of substituted 4-quinolone derivatives from substituted 3-(2-halophenyl)-3-oxopropane, aldehydes and aq. NH3 using water as an environmentally benign reaction media. Moreover, the synthetic utility of the obtained products has been successfully applied for the synthesis of available oxolinic acid and BQCA drugs. The key features of this approach include commercially available starting materials, broad scope, and moderate to good reaction yields. Reaction with formaldehyde, and other functionalities such as ?CN, ?NO2, ?SO2Ar, and ?COAr were also successful. In addition, reaction with heterocyclic compounds such as 3-(3-bromothiophen-2-yl)-3-oxopropanenitrile proceeded smoothly to afford tetrahydrothieno[3,2-b]pyridine-6-carbonitrile analogues. The practicality of the designed protocol was confirmed by gram scale synthesis of two derivatives. (Figure presented.).

Dibenzonaphthyridine derivatives and methods of use thereof

The present invention relates to Dibenzonaphthyridine Derivatives, compositions comprising an effective amount of a Dibenzonaphthyridine Derivative and methods for treating or preventing a proliferative disorder, comprising administering to a subject in need thereof an effective amount of a Dibenzonaphthyridine Derivative.

AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS

The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: where R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.