214822-98-7

Basic information

• Product Name: methyl 4-fluoro-3-(prop-2-yn-1-yloxy)benzoate
• Synonyms: benzoic acid, 4-fluoro-3-(2-propyn-1-yloxy)-, methyl ester; Methyl 4-fluoro-3-(prop-2-yn-1-yloxy)benzoate
• CAS NO: 214822-98-7
• Molecular Formula: C₁₁H₉FO₃
• Molecular Weight: 208.1858
• Mol File: 214822-98-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 302.257°C at 760 mmHg
• Flash Point: 132.264°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: methyl 4-fluoro-3-(prop-2-yn-1-yloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-fluoro-3-(prop-2-yn-1-yloxy)benzoate(214822-98-7)
• EPA Substance Registry System: methyl 4-fluoro-3-(prop-2-yn-1-yloxy)benzoate(214822-98-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 214822-98-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9FO3/c1-3-6-15-10-7-8(11(13)14-2)4-5-9(10)12/h1,4-5,7H,6H2,2H3

Upstream product

• 106-96-7 propargyl bromide 
• 214822-96-5 4-Fluoro-3-hydroxy-benzoic acid methyl ester 
• 51446-31-2 4-fluoro-3-hydroxybenzoic acid 

Downstream Products

• 843653-25-8 3-{cyclobutyl[3-(5-fluoro-1H-indol-3-yl)propyl]amino}-8-fluorochromane-5-carboxamide 

Relevant articles and documents

Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Compounds containing a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2H-1- benzopyran and a 3-alkylindole moiety linked through a common basic nitrogen were prepared and evaluated for 5-HT1A affinity, serotonin rat transporter affinity, and functional antagonist activity in vitro. 26a was found to be the most potent and selective compound in this series and was shown to possess neurochemical activity in vivo by producing acute and rapid increases in 5-HT in the rat frontal cortex.

Process for the manufacture of 3-N-N-dicyclobutylamino-8-fluoro-3, 4-dihydro-2H-1-benzopyran-5-carboxamide

A process for the manufacture of the racemic compound of the formula (I), its R-enantiomer (formula R-(I)) and its S-enantiomer (formula S-(I)), and pharmaceutically acceptable salts and/or solvates thereof, as well as new intermediates obtained and used in the process.