2150-42-7

Basic information

• Product Name: METHYL 2,3-DIMETHOXY BENZOATE
• Synonyms: METHYL 2,3-DIMETHOXY BENZOATE;RARECHEM AL BF 0023;2,3-Dimethoxybenzoic acid methyl ester;Methyl o-veratrate;o-Veratric acid methyl ester;Methyl 2,3-dimethoxybenzoate 97%
• CAS NO: 2150-42-7
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• EINECS: 218-425-7
• Product Categories: C10 to C11;Carbonyl Compounds;Esters
• Mol File: 2150-42-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 48-52 °C(lit.)
• Boiling Point: 180-185 °C50 mm Hg(lit.)
• Flash Point: 110 °C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0.00501mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2,3-DIMETHOXY BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,3-DIMETHOXY BENZOATE(2150-42-7)
• EPA Substance Registry System: METHYL 2,3-DIMETHOXY BENZOATE(2150-42-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 2150-42-7(Hazardous Substances Data)

Usage

General Description

Methyl 2,3-dimethoxy benzoate, also known as veratraldehyde methyl ether, is an organic compound with the chemical formula C10H12O4. It is a colorless to slightly yellow liquid with a sweet, floral odor. This chemical is commonly used in the fragrance and flavor industries, as well as in the production of pharmaceuticals and agrochemicals. It is often employed as a flavoring agent in food and beverages, and as a fragrance ingredient in perfumes and personal care products. Methyl 2,3-dimethoxy benzoate is also utilized in the synthesis of various pharmaceutical intermediates.

InChI:InChI=1/C10H12O4/c1-12-8-6-4-5-7(9(8)13-2)10(11)14-3/h4-6H,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 877-22-5 3-methoxysalicylic acid 
• 67-56-1 methanol 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 77-78-1 dimethyl sulfate 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 59276-32-3 2,3-dimethoxybenzaldehyde dimethylacetal 
• 92720-69-9 (2,3-Dimethoxy-phenyl)-methoxy-methyl-hydroperoxide 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 91-16-7 1,2-dimethoxybenzene 
• 79-22-1 methyl chloroformate 
• 68-12-2 N,N-dimethyl-formamide 
• 99-50-3 3,4-Dihydroxybenzoic acid 

Downstream Products

• 37388-12-8 1-isopropenyl-2,3-dimethoxy-benzene 
• 153390-68-2 2-<2,3-dimethoxyphenyl>-propan-2-ol 
• 30577-88-9 2,3-dimethoxy-benzoic acid benzylamide 
• 528830-98-0 ethyl 3-(2,3-dimethoxyphenyl)-3-oxopropanoate 
• 872793-76-5 (2,3-Dimethoxy-phenyl)-diphenyl-methanol 
• 33708-63-3 1-((E)-2-Cyclohexyl-1-cyclohexylmethyl-vinyl)-2,3-dimethoxy-benzene 
• 33551-28-9 C₂₃H₃₈O₂ 
• 82478-18-0 3-Methoxy-1-methyl-cyclohexa-2,5-dienecarboxylic acid methyl ester 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 
• 198351-02-9 8-Allyl-2-(2,3-dimethoxy-phenyl)-chromen-4-one 
• 6342-70-7 3-methoxymethylsalicylate 
• 850254-51-2 5‐bromo‐1‐isopropyl‐2,3‐dimethoxybenzene 
• 181016-78-4 5-bromo-1-isopropenyl-2,3-dimethoxybenzene 
• 181016-77-3 2‐(5‐bromo‐2,3‐dimethoxyphenyl)propan‐2‐ol 

Relevant articles and documents

Dihydroxylation Studies of Isoquinolinones: Synthesis of the EF-Ring of Lysolipin i

Inspired by the potent polycyclic xanthone antibiotic lysolipin I, a general study on asymmetric dihydroxylation reactions of variously substituted isoquinolinones was performed. Different isoquinolinones were efficiently prepared, either by a Pomeranz-Fritsch type condensation or a Curtius rearrangement. Under a broad variety of conventional oxygenation procedures, they proved very unreactive. However, either by suitable substitution of the appending aromatic ring or more forcing conditions a dihydroxylation could finally be performed, which allowed the synthesis of the EF-ring of lysolipin I.

Alkylation of substituted benzoic acids in a continuous flow microfluidic microreactor: Kinetics and linear free energy relationships

Alkylation of para-substituted benzoic acids by iodomethane using an organic superbase, 1,8-bis(tetramethylguanidino)naphthalene (TMGN) in DMF was chosen as a model reaction to test the quality of the control of experimental parameters in a continuous flow microfluidic reactor as it is expected to follow a perfect second order kinetics with a large dynamics by varying the substituents. These conditions may be directly used for the synthesis of natural product esters. Because TMGN reacts slowly with iodomethane, the three different mixing strategies between substrate, base and alkylating reagent were compared. The rate constants were determined for the reaction with a set of alkylating agents and in different solvents. In order to test the quality of the obtained data, temperature effect and free energy relationships, which are expected to follow predictable laws, were investigated. The kinetics vary over 6 orders of magnitude and follows a perfect Arrhenius law, allowing the determination of the energies, enthalpies, and entropies of activation. Finally, we established a Hammett linear relationship for a series of 16 substituted benzoic acids, leading to a reaction constant ρ of -0.65 for this reaction. The quality of the obtained kinetics allowed us to discuss the outliers. All kinetics were obtained with less than 0.5 mmol of substrate.

COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME

The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.