21573-69-3

Basic information

• Product Name: 1-Phenylcyclopentanecarboxaldehyde
• Synonyms: 1-Phenylcyclopentanecarboxaldehyde;1-Phenylcyclopentane-1-carbaldehyde;1-Phenylcyclopentanecarbaldehyde;Cyclopentanecarboxaldehyde,1-phenyl-;1-Phenyl-1-cyclopentanecarboxaldehyde;1-Phenylcyclopentanecarboxyaldehyde
• CAS NO: 21573-69-3
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• Mol File: 21573-69-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 134℃ (15 Torr)
• Flash Point: 95.9±14.0℃
• Appearance: /
• Density: 1.103±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1-Phenylcyclopentanecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylcyclopentanecarboxaldehyde(21573-69-3)
• EPA Substance Registry System: 1-Phenylcyclopentanecarboxaldehyde(21573-69-3)

Safety Data

• Hazardous Substances Data: 21573-69-3(Hazardous Substances Data)

Usage

General Description

1-Phenylcyclopentanecarboxaldehyde is a chemical compound with the molecular formula C12H14O. It is an aldehyde, which means it contains a carbonyl group (C=O) bonded to a hydrogen atom and an R group. The R group in this compound is a phenyl group attached to a cyclopentane ring. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and fragrances. It is also used as a flavoring agent in the food industry. Additionally, 1-Phenylcyclopentanecarboxaldehyde has been studied for its potential biological activities, such as antioxidant and anti-inflammatory properties. However, it should be handled with care as it can be irritating to the skin, eyes, and respiratory system.

InChI:InChI=1/C12H14O/c13-10-12(8-4-5-9-12)11-6-2-1-3-7-11/h1-3,6-7,10H,4-5,8-9H2

Upstream product

• 5775-23-5 1-phenylcyclohexene oxide 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 77-57-6 1-phenyl-1-cyclopentanecarbonitrile 
• 17380-62-0 1-phenylcyclopentanecarboxylic acid chloride 
• 59115-90-1 1-hydroxymethyl-1-phenylcyclopentane 
• 110-52-1 1,4-dibromo-butane 
• 26939-22-0 2-benzyl-4,4,6-trimethyl-5,6-dihydro-4H-[1,3]oxazine 
• 67-56-1 methanol 
• 4829-01-0 (-)-(1S,2S)-1-phenylcyclohex-1-ene oxide 
• 64-17-5 ethanol 
• 19324-77-7 2-chloro-1-phenylcyclohexan-1-ol 
• 97273-03-5 2-Cyclohexyl-3-phenyl-1,2-thiazetidin-1,1-dioxid 
• 4535-95-9 1-ethoxycarbonyl-1-phenylcyclopentane 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 1812-68-6 1-phenyl-cyclopentanecarbaldehyde-(2,4-dinitro-phenylhydrazone) 
• 1026648-58-7 2-(Diphenyl-phosphinoyl)-2-methoxy-1-(1-phenyl-cyclopentyl)-ethanol 
• 166878-43-9 4-benzyl-5-phenyl-3-(1-phenylcyclopentyl)-1,2,4-dioxazolidine 
• 1016970-19-6 1-(1-phenylcyclopentyl)non-2-ynyl acetate 
• 1016970-18-5 1-(1-phenylcyclopentyl)prop-2-ynyl acetate 
• 1092352-06-1 (1-ethynylcyclopentyl)benzene 
• 59115-90-1 1-hydroxymethyl-1-phenylcyclopentane 
• 5407-84-1 β-phenyl-β,β-tetramethylenepropionitrile 
• 1616922-13-4 2-cyclopropyl-9-hydroxy-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-53-8 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopropylamide 
• 1616924-54-9 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid cyclopropyl(2-hydroxyethyl)amide 
• 1616924-55-0 9-benzyloxy-2-cyclopropyl-6-(1-phenylcyclopentylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-57-2 5-benzyloxy-6-hydroxy-2-(1-phenylcyclopentylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]cyclopentylamide 

Relevant articles and documents

A first homogeneous gold(III)-catalysed epoxidation of aromatic alkenes

The first example of a homogeneous gold(III)-catalysed epoxidation of aromatic alkenes at room temperature using sodium chlorite as the stoichiometric oxidant in a homogeneous trisolvent system of 2-methoxyethanol/acetonitrile/ water (volume ratio: 1/3/1)

Kinetic Resolution of Neopentylic Secondary Alcohols by Cu-H-Catalyzed Enantioselective Silylation with Hydrosilanes

A nonenzymatic kinetic resolution of sterically congested alcohols having a quaternary carbon atom in the β-position is reported. The catalyst system CuCl/NaOtBu/(R,R)-Ph-BPE together with a 3,5-xylyl-substituted tertiary hydrosilane enable enantioselective silylation of the hydroxy group. Several alcohols are obtained with good to excellent selectivity factors, and there are no other known straightforward methods to access these motifs.

Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes

The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.

Regioselective 1,2-Diol Rearrangement by Controlling the Loading of BF3·Et2O and Its Application to the Synthesis of Related Nor-Sesquiterene- and Sesquiterene-Type Marine Natural Products

The regiocontrolled rearrangement of 1,2-diols has been achieved by controlling the loading of BF3·Et2O. Its applicability is showcased by the divergent synthesis of austrodoral, austrodoric acid, and 8-epi-11-nordriman-9-one, as well as a formal synthesis of siphonodictyal B and liphagal. A new light is shed on piancol-type rearrangements that will be useful in diversity-oriented synthesis of related natural products.