215734-58-0

Basic information

• Product Name: Quinoxaline, 6,7-difluoro-
• CAS NO: 215734-58-0
• Molecular Formula: C8H4F2N2
• Molecular Weight: 166.13
• Mol File: 215734-58-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Quinoxaline, 6,7-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoxaline, 6,7-difluoro-(215734-58-0)
• EPA Substance Registry System: Quinoxaline, 6,7-difluoro-(215734-58-0)

Safety Data

• Hazardous Substances Data: 215734-58-0(Hazardous Substances Data)

Upstream product

• 131543-46-9 Glyoxal 
• 76179-40-3 2-amino-4,5-difluoroaniline 

Downstream Products

• 602-04-0 tris(2-methyl-1H-indol-3-yl)methane 
• 78581-99-4 5,6-difluoro-1H-benzo[d]imidazole 
• 920034-10-2 7-amino-6-fluoroquinoxaline 
• 333452-15-6 7-fluoroquinoxalin-6-ylhydrazine 
• 6295-29-0 6,7-Dimethoxyquinoxaline 

Relevant articles and documents

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids

An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.

Fluorinated Quinoxalines: Synthesis and Alkylation

6,7-Difluoro- and 6-fluoro-7-morpholino(4-methylpiperazinyl, 2,6-dimethylpiperazinyl)quinoxalines have been synthesized from aromatic diamines and glyoxal, and their alkylation with Meerwein reagent has been studied. A procedure has been developed for preparation of pure 1-ethylquinoxalinium salts whose structure has been confirmed by 1H NMR spectra and X-ray analysis.